| Brand Name | Simponi |
| Generic Name | Golimumab |
| Drug Class | Anti-TNF-alpha Monoclonal Antibody |
| Availability | Prescription |
| Manufacturer | Janssen Biotech (Johnson & Johnson) |
| Indications | Ulcerative Colitis, Crohn's Disease |
| Type | Injection |
| Doses | 200 mg (induction) at weeks 0, 2, 4, then 100 mg every 4 weeks for maintenance. |
| Route | Subcutaneous (SC) |
| Side Effects | Injection site reactions, upper respiratory infections, fatigue |
| Interactions | TNF-alpha blocker; similar interaction profile as adalimumab |
| Overdose | Infection, injection-site reactions. |
| Missed Dose | Take ASAP or resume on schedule. |
| Contraindications | Active TB, infections, demyelinating diseases. |
| Alternatives | Golimumab, Vedolizumab |
| Co-Pay Assistance Program | Available Rx |
| Patient Assistance Program | Available |
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Golimumab is used to treat autoimmune diseases such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis by blocking tumor necrosis factor-alpha (TNF-alpha).
Golimumab works by binding to TNF-alpha, a protein involved in inflammation, and blocking its action to reduce the inflammatory response in affected tissues.
Common side effects include injection site reactions, upper respiratory infections, and headaches. Serious side effects may include serious infections and liver problems.
Golimumab is administered as a subcutaneous injection, typically every four to eight weeks, depending on the specific condition being treated.
Yes, Golimumab is also used to treat psoriatic arthritis and ulcerative colitis, in addition to rheumatoid arthritis.
If you miss a dose of Golimumab, take it as soon as you remember unless it�s almost time for your next dose. Contact your healthcare provider for guidance.
Golimumab should only be used during pregnancy if absolutely necessary. It is important to discuss the risks and benefits with your healthcare provider if you are pregnant or planning to become pregnant.
Yes, Golimumab can cause allergic reactions in some people. Seek immediate medical attention if you experience symptoms such as rash, difficulty breathing, or swelling of the face or throat.
Golimumab is highly effective in treating psoriatic arthritis, significantly improving symptoms such as joint pain, swelling, and skin lesions in many patients.
Golimumab may interact with other immunosuppressive medications. Be sure to inform your healthcare provider about any other treatments you are using.
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