| Brand Name | Zydelig |
| Generic Name | Idelalisib |
| Drug Class | PI3K Inhibitor |
| Availability | Prescription |
| Manufacturer | Gilead Sciences |
| Indications | Ulcerative Colitis, Crohn's Disease |
| Type | Tablet |
| Doses | Oral: 150 mg twice daily (induction), 150 mg daily (maintenance) |
| Route | Oral |
| Side Effects | Diarrhea, nausea, fatigue, liver enzyme elevation, infections |
| Interactions | PI3K inhibitor; avoid CYP3A inhibitors and monitor for infections |
| Overdose | Liver toxicity, diarrhea, infection risk. |
| Missed Dose | Take ASAP; skip if near next. |
| Contraindications | Severe hepatic impairment, active TB or serious infections. |
| Alternatives | Upadacitinib, Filgotinib |
| Co-Pay Assistance Program | Available Rx |
| Patient Assistance Program | Available |
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Tofacitinib is applied in managing mild to moderate to severe rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis with the inhibition of Janus kinase (JAK) enzymes in the inflammatory process.
Tofacitinib is obtained by blocking JAK-enzymes which becomes highly important in the immune system signaling pathways, thereby decreasing inflammation and tissue damages.
The side effects are upper respiratory infections, headache, and high blood pressure, which are common. Severe side effects are also possible such as blood clots and infections.
Tofacitinib is administered as pills and is normally taken once or twice in a day, depending on the type of ailment one is afflicted with and the dosage prescribed.
Yes, Tofacitinib can cause intense infection. Infection signs and symptoms should be checked, and the doctor should be contacted in case of any symptoms.
The use of tofacitinib during pregnancy needs to have an advantage over the disadvantage. Talk with your medical practitioner about whether you are pregnant or about having pregnancy.
In case you miss a dose take the overdue dose immediately you remember until the time of the immediate dose is soon approaching. Do not take two doses at once.
Tofacitinib can be used alongside other immunosuppressive drugs hence it is crucial to notify your doctor on all the medications that you take.
Tofacitinib can require weeks or even months before its effects can be noticed especially in cases such as rheumatoid arthritis and ulcerative colitis.
Tofacitinib has demonstrated its efficacy in the treatment of moderate to severe ulcerative colitis to induce and maintain remission in a good number of the individuals.
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