| Brand Name | Entyvio (Subcutaneous) |
| Generic Name | Vedolizumab |
| Drug Class | Integrin Receptor Antagonist |
| Availability | Prescription |
| Manufacturer | Takeda Pharmaceuticals |
| Indications | Ulcerative Colitis, Crohn's Disease |
| Type | IV Infusion |
| Doses | Initial: 300 mg at weeks 0, 2, and 6, then every 8 weeks for maintenance |
| Route | SC Injection |
| Side Effects | Headache, constipation, fatigue |
| Interactions | Monoclonal antibody; avoid with live vaccines; risk of infections |
| Overdose | Headache, infections. |
| Missed Dose | Infusion-based; reschedule ASAP. |
| Contraindications | Active infections, PML risk |
| Alternatives | Upadacitinib, Filgotinib |
| Co-Pay Assistance Program | Not available |
| Patient Assistance Program | Available |
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Vedolizumab is used to treat inflammatory bowel diseases like Crohn's disease and ulcerative colitis by reducing inflammation in the gastrointestinal tract.
Vedolizumab works by targeting and blocking integrin receptors, which help immune cells to enter the inflamed parts of the intestines, thus reducing inflammation.
Common side effects include headache, joint pain, and upper respiratory infections. Rare but serious side effects may include allergic reactions or liver problems.
Vedolizumab is administered as an intravenous (IV) infusion by a healthcare provider. The dosing schedule varies based on the condition being treated.
Vedolizumab should only be used during pregnancy if the benefits outweigh the risks. Discuss with your doctor if you are pregnant or planning to become pregnant.
Vedolizumab may interact with other medications, especially those that affect the immune system. Inform your healthcare provider of all medications you are taking.
If you miss a dose of Vedolizumab, contact your healthcare provider for guidance. Do not attempt to administer the medication yourself.
Vedolizumab helps by blocking the action of specific immune cells in the intestines, reducing inflammation, and improving symptoms in people with Crohn�s disease and ulcerative colitis.
Yes, Vedolizumab can increase the risk of infections due to its effects on the immune system. Your healthcare provider will monitor you for infections during treatment.
It can take several weeks to months to see the full benefits of Vedolizumab in treating inflammatory bowel diseases like Crohn's and ulcerative colitis.
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