| Brand Name | Zofran |
| Generic Name | Ondansetron |
| Drug Class | Dopamine (D2) Antagonist |
| Availability | Prescription |
| Manufacturer | GlaxoSmithKline |
| Indications | Nausea, Vomiting |
| Type | Tablet, Oral Solution, Injection |
| Doses | 4-8 mg every 8 hours |
| Route | Oral, IV |
| Side Effects | Headache, constipation, dizziness, QT prolongation |
| Interactions | May prolong QT interval; interacts with serotonergic drugs |
| Overdose | Irregular heartbeat, dizziness, headache. |
| Missed Dose | Take ASAP; skip if near next. |
| Contraindications | Hypersensitivity to ondansetron, apomorphine use, congenital QT syndrome. |
| Alternatives | Granisetron, Palonosetron, Dolasetron |
| Co-Pay Assistance Program | Available Rx |
| Patient Assistance Program | Available |
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Ondansetron is used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery.
Ondansetron works by blocking serotonin receptors in the brain and gastrointestinal tract that trigger nausea and vomiting.
Common side effects include headache, constipation, dizziness, and fatigue.
Yes, Ondansetron can be taken with or without food.
Ondansetron should only be used during pregnancy if the potential benefit justifies the risk. Consult your doctor before use.
If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. Do not take two doses at once.
Ondansetron typically starts working within 30 minutes to an hour to prevent nausea and vomiting.
Ondansetron is generally used short-term, especially for chemotherapy-related nausea. Long-term use should be monitored by a healthcare provider.
Yes, Ondansetron can interact with medications such as certain antidepressants, anti-seizure drugs, and medications that affect the heart.
If you experience severe side effects like chest pain or irregular heartbeats, seek immediate medical attention.
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