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Zofran - Ondansetron

Bharat Pothuri Medically Reviewed by Dr. Bharat Pothuri, MD, FACG
Brand Name
Zofran
Generic Name
Ondansetron
Drug Class
Dopamine (D2) Antagonist
Availability
Prescription
Manufacturer
GlaxoSmithKline
Indications
Nausea, Vomiting
Type
Tablet, Oral Solution, Injection
Doses
4-8 mg every 8 hours
Route
Oral, IV
Side Effects
Headache, constipation, dizziness, QT prolongation
Interactions
May prolong QT interval; interacts with serotonergic drugs
Overdose
Irregular heartbeat, dizziness, headache.
Missed Dose
Take ASAP; skip if near next.
Contraindications
Hypersensitivity to ondansetron, apomorphine use, congenital QT syndrome.
Alternatives
Granisetron, Palonosetron, Dolasetron
Co-Pay Assistance Program
Available Rx
Patient Assistance Program
Available

Frequently Asked Questions

What is Ondansetron used for?

Ondasetron is employed in preventing nausea and vomiting as a result of chemotherapy, radiation therapy and surgery.

How does Ondansetron work?

The mechanism of Ondansetron is to block serotonin receptors in the brain and gastrointestinal tract which cause nausea and vomiting.

Which are the most frequent side effects of Ondansetron?

Side effects are headache, constipation, dizziness, and fatigue.

Should Ondansetron be used with food?

Yes Ondansetron may be used with or without food.

Does Ondansetron pass through pregnancy?

Use of Ondansetron in pregnant women should be as a result of the possible benefit versus the risk of the drug. Use under the guidance of the doctor.

What do I do when I fall behind on a dose of Ondansetron?

In case of missing a dose, do it as soon as possible without considering it to be almost time to take your next dose. Do not take two doses at once.

What is the time of action of Ondansetron?

Ondansetron normally takes between 30 to an hour to take effect to prevent nausea and vomiting.

Is Ondansetron safe on a long-term basis?

The generic is usually taken on a short-term basis particularly nausea caused by chemotherapy. A healthcare provider should observe long-term usage.

Is Ondansetron potentially interactive with drugs?

Yes, Ondansetron may have an interaction with some certain antidepressants, anti-seizure drugs, and heart-related drugs.

What are some of the side effects of Ondansetron?

In case you are affected by any serious side effects such as chest pain or irregular heartbeats, consult a physician at once.