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Varubi

Rolapitant

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Varubi - Rolapitant

Bharat Pothuri Medically Reviewed by Dr. Bharat Pothuri, MD, FACG
Brand Name
Varubi
Generic Name
Rolapitant
Drug Class
NK1 Receptor Antagonist
Availability
Prescription
Manufacturer
Tesaro, Inc.
Indications
Chemotherapy-Induced Nausea and Vomiting (CINV)
Type
Tablet
Doses
180 mg oral once before chemotherapy
Route
Oral
Side Effects
Neutropenia, hiccups, decreased appetite, dizziness
Interactions
May interact with CYP3A4 inhibitors, warfarin, clopidogrel
Overdose
Overdose information is limited; seek immediate medical attention if overdose is suspected.
Missed Dose
Take the missed dose as soon as possible. If it's almost time for the next dose, skip the missed dose and resume your regular schedule. Do not double doses.
Contraindications
Hypersensitivity; avoid with CYP3A4 substrates like pimozide.
Alternatives
Aprepitant, Fosaprepitant, Netupitant
Co-Pay Assistance Program
Available
Patient Assistance Program
Available

Frequently Asked Questions

What is Rolapitant used for?

Rolapitant is the medication that is used in the prevention of nausea and vomiting related to chemotherapy. It acts by antagonistic action of the neurokinin-1 (NK1) receptor in the brain.

How does Rolapitant work?

Rolapitant inhibits the neurokinin-1 receptor whose action is important in vomiting reflex. Rolapitant inhibits the nausea and vomiting caused by chemotherapy by inhibiting this receptor.

Which are the traditional side effects of Rolapitant?

The side effects are usually fatigue, dizziness, and constipation. The side effects are serious but not common and may consist of allergic reactions or liver damage.

What is the best mode of administration of Rolapitant?

Rolapitant comes in iv (infusion) and oral administration before chemotherapy. The dosage should be taken depending on your treatment plan.

Does Rolapitant make it through pregnancy?

Pregnancy when taking Rolapitant must be determined as beneficial as compared to the side effects. It is absorbed during pregnancy, so consult with your healthcare provider.

What are the data concerning missing a dosage of Rolapitant?

In case you forget to take a dose, then take the medicine immediately, but never before it gets to the time when the next dose is to be taken. Do not take two doses at once.

Is Rolapitant applicable in motion sickness?

Rolapitant is a drug that is specifically used in the prevention of nausea and vomiting caused by chemotherapy, not in preventing motion sickness. Motion sickness could be treated with other drugs.

What is the time of action of Rolapitant?

Rolapitant begins its action within few hours to prevent nausea and vomiting following chemotherapy the effects of which last up to 5 days after the drug is taken.

Does Rolapitant have a drug interaction?

There are potential interactions between rolapitant and other drugs, especially the hepatic drugs. Never forget to notify your health care provider on all the medications.

Is it possible to use Rolapitant in combination with other anti-nausea drugs?

Yes, the use of Rolapitant with other anti-nausea drugs 5-HT3 or corticosteroids is usually intended to complement its effects in the prevention of chemotherapy-induced nausea and vomiting.