| Brand Name | Varubi |
| Generic Name | Rolapitant |
| Drug Class | NK1 Receptor Antagonist |
| Availability | Prescription |
| Manufacturer | Tesaro, Inc. |
| Indications | Chemotherapy-Induced Nausea and Vomiting (CINV) |
| Type | Tablet |
| Doses | 180 mg oral once before chemotherapy |
| Route | Oral |
| Side Effects | Neutropenia, hiccups, decreased appetite, dizziness |
| Interactions | May interact with CYP3A4 inhibitors, warfarin, clopidogrel |
| Overdose | Overdose information is limited; seek immediate medical attention if overdose is suspected. |
| Missed Dose | Take the missed dose as soon as possible. If it's almost time for the next dose, skip the missed dose and resume your regular schedule. Do not double doses. |
| Contraindications | Hypersensitivity; avoid with CYP3A4 substrates like pimozide. |
| Alternatives | Aprepitant, Fosaprepitant, Netupitant |
| Co-Pay Assistance Program | Available |
| Patient Assistance Program | Available |
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Rolapitant is used to prevent nausea and vomiting associated with chemotherapy. It works by blocking the neurokinin-1 (NK1) receptor in the brain.
Rolapitant blocks the neurokinin-1 receptor, which plays a key role in the vomiting reflex. By blocking this receptor, Rolapitant helps prevent chemotherapy-induced nausea and vomiting.
Common side effects include fatigue, dizziness, and constipation. Serious side effects are rare but may include allergic reactions or liver damage.
Rolapitant is typically administered as an intravenous (IV) infusion or taken orally before chemotherapy. The dosage depends on your specific treatment regimen.
Rolapitant should be used during pregnancy only if the potential benefits outweigh the risks. Consult your healthcare provider before using it during pregnancy.
If you miss a dose, take it as soon as you remember, unless it's almost time for the next dose. Do not take two doses at once.
Rolapitant is specifically designed for preventing chemotherapy-induced nausea and vomiting, not for motion sickness. Other medications may be better suited for motion sickness.
Rolapitant starts working within a few hours to prevent nausea and vomiting after chemotherapy, with its effects lasting for up to 5 days after administration.
Rolapitant may interact with other medications, particularly those affecting the liver. Always inform your healthcare provider about all medications you're taking.
Yes, Rolapitant is often used in combination with other anti-nausea medications such as 5-HT3 antagonists or corticosteroids to enhance efficacy in preventing chemotherapy-induced nausea and vomiting.
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