| Brand Name | Propulsid |
| Generic Name | Cisapride |
| Drug Class | NK1 Receptor Antagonist |
| Availability | Prescription |
| Manufacturer | Janssen Pharmaceutical |
| Indications | Chronic Constipation |
| Type | Tablet (Discontinued in many regions) |
| Doses | 10 mg orally 3 times daily |
| Route | Oral |
| Side Effects | Diarrhea, abdominal cramps, QT prolongation (serious, rare) |
| Interactions | Contraindicated with drugs prolonging QT interval; CYP3A4 inhibitors |
| Overdose | Overdose symptoms may include nausea, vomiting, rumbling noises in the stomach, flatulence, diarrhea, urinary frequency, tremors, seizures, and weakness. |
| Missed Dose | Take the missed dose as soon as you remember. If it's almost time for the next dose, skip the missed dose and resume your regular schedule. Do not double doses. |
| Contraindications | QT prolongation, ventricular arrhythmias, concurrent CYP3A4 inhibitors. |
| Alternatives | Metoclopramide, Domperidone, Prucalopride |
| Co-Pay Assistance Program | Available |
| Patient Assistance Program | Not available |
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Cisapride is used to treat gastrointestinal motility disorders, such as gastroparesis, and to improve the movement of food through the stomach and intestines.
Cisapride works by increasing the movement of the stomach and intestines, enhancing gastrointestinal motility, and improving food passage through the digestive tract.
Common side effects include abdominal cramps, diarrhea, and headache. Serious side effects may include heart arrhythmias and QT prolongation.
Cisapride is typically taken orally in tablet form. The dosage and frequency depend on the condition being treated, so follow your healthcare provider�s instructions.
Yes, Cisapride can cause serious heart problems, including QT prolongation, which may lead to arrhythmias. This risk is why Cisapride is generally avoided in many countries.
Cisapride should not be used during pregnancy due to potential risks to the fetus. Consult your healthcare provider for alternative treatments during pregnancy.
If you miss a dose, take it as soon as you remember, unless it�s almost time for your next dose. Do not take two doses at once.
Yes, Cisapride can interact with several medications, especially those affecting heart rhythm or metabolism. Inform your healthcare provider about all medications you are taking.
Cisapride typically works within a few hours to improve motility, but it may take longer for symptoms like bloating or nausea to resolve.
While Cisapride is primarily used for motility issues like gastroparesis, it may help with constipation caused by slow gastric emptying. Always use it under medical supervision due to potential heart risks.
