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Propulsid - Cisapride

Bharat Pothuri Medically Reviewed by Dr. Bharat Pothuri, MD, FACG
Brand Name
Propulsid
Generic Name
Cisapride
Drug Class
NK1 Receptor Antagonist
Availability
Prescription
Manufacturer
Janssen Pharmaceutical
Indications
Chronic Constipation
Type
Tablet (Discontinued in many regions)
Doses
10 mg orally 3 times daily
Route
Oral
Side Effects
Diarrhea, abdominal cramps, QT prolongation (serious, rare)
Interactions
Contraindicated with drugs prolonging QT interval; CYP3A4 inhibitors
Overdose
Overdose symptoms may include nausea, vomiting, rumbling noises in the stomach, flatulence, diarrhea, urinary frequency, tremors, seizures, and weakness.
Missed Dose
Take the missed dose as soon as you remember. If it's almost time for the next dose, skip the missed dose and resume your regular schedule. Do not double doses.
Contraindications
QT prolongation, ventricular arrhythmias, concurrent CYP3A4 inhibitors.
Alternatives
Metoclopramide, Domperidone, Prucalopride
Co-Pay Assistance Program
Available
Patient Assistance Program
Not available

Frequently Asked Questions

What is Cisapride used for?

Cisapride is used to treat gastrointestinal motility disorders, such as gastroparesis, and to improve the movement of food through the stomach and intestines.

How does Cisapride work?

Cisapride works by increasing the movement of the stomach and intestines, enhancing gastrointestinal motility, and improving food passage through the digestive tract.

What are the common side effects of Cisapride?

Common side effects include abdominal cramps, diarrhea, and headache. Serious side effects may include heart arrhythmias and QT prolongation.

How should Cisapride be taken?

Cisapride is typically taken orally in tablet form. The dosage and frequency depend on the condition being treated, so follow your healthcare provider�s instructions.

Can Cisapride cause heart problems?

Yes, Cisapride can cause serious heart problems, including QT prolongation, which may lead to arrhythmias. This risk is why Cisapride is generally avoided in many countries.

Is Cisapride safe during pregnancy?

Cisapride should not be used during pregnancy due to potential risks to the fetus. Consult your healthcare provider for alternative treatments during pregnancy.

What should I do if I miss a dose of Cisapride?

If you miss a dose, take it as soon as you remember, unless it�s almost time for your next dose. Do not take two doses at once.

Can Cisapride interact with other medications?

Yes, Cisapride can interact with several medications, especially those affecting heart rhythm or metabolism. Inform your healthcare provider about all medications you are taking.

How long does it take for Cisapride to work?

Cisapride typically works within a few hours to improve motility, but it may take longer for symptoms like bloating or nausea to resolve.

Can Cisapride be used for constipation?

While Cisapride is primarily used for motility issues like gastroparesis, it may help with constipation caused by slow gastric emptying. Always use it under medical supervision due to potential heart risks.