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Emend

Aprepitant

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Emend - Aprepitant

Bharat Pothuri Medically Reviewed by Dr. Bharat Pothuri, MD, FACG
Brand Name
Emend
Generic Name
Aprepitant
Drug Class
Neurokinin-1 (NK1) Receptor Antagonist
Availability
Prescription
Manufacturer
Merck & Co.
Indications
Chemotherapy-Induced Nausea and Vomiting (CINV)
Type
Capsule, Oral Suspension
Doses
125 mg orally on day 1, then 80 mg daily for 2 days
Route
Oral
Side Effects
Fatigue, hiccups, constipation, nausea, dizziness
Interactions
May interact with warfarin, oral contraceptives, dexamethasone, ketoconazole, atazanavir.
Overdose
Fatigue, hiccups, dizziness, GI symptoms. Generally well tolerated.
Missed Dose
Take ASAP before chemotherapy session. Skip if too late; consult oncologist.
Contraindications
Concurrent use with pimozide, hypersensitivity to aprepitant
Alternatives
Ondansetron (5-HT3 receptor antagonist, often used as a first-line anti-nausea drug) Granisetron (5-HT3 receptor antagonist) Dexamethasone (steroid used in combination with other anti-nausea medications for chemotherapy) Metoclopramide (prokinetic agent, also effective for nausea)
Co-Pay Assistance Program
Available
Patient Assistance Program
Available

Frequently Asked Questions

What is Aprepitant used for?

The use of aprepatinant is in the prevention of chemotherapy and surgery induced nausea and vomiting. It works by preventing neurokinin-1 (NK1) receptor in the brain.

How does Aprepitant work?

Mechanism of action Apratinib inhibits neurokinin-1 receptor which is a part of vomiting reflex and prevents vomiting and nausea during the chemotherapy or surgery.

What are some of the most common side effects of Aprepentin?

The side effects include constipation, fatigue and dizziness amongst others. The side effects may be extremely severe such as hepatic or allergies.

How do Aprepentin and Aprepentin work?

Aprepitant is mostly administered orally in the form of capsules in a normal manner one hour before chemotherapy. It can be used along with other anti-nauseal medicine.

Should Aprepitant be used when pregnant?

In this situation, Pregnancy Aparetin must be used only in the situations when the benefit of use of the drug is greater than the harm. Do not forget to ask your health practitioner in the event of becoming pregnant.

But what then shall I do? in case of forgottenness of Aprepritant?

You are expected to take your dose as soon as you remember without such a period lest you forget to take your dose. Do not take two doses at once.

Usability of Aprepitant in the case of motion sickness?

Aprepitant would not be applied in motion sickness, whereas has been proved to be suitable in the prevention of nausea and vomiting as side effects of chemotherapy or surgery.

What is the action time of Aprepitant?

Aprepitant is a rapid response medication and habitually it shall occur about an hour after the intake of medications to avoid vomiting and nausea effect brought about by chemotherapy or surgery.

Drug-drug interaction with Aprepitant drug?

Apeptinant is likely to react with other drugs particularly those that can possibly act on liver as it is disintegrated by liver enzymes. You should never forget to tell your health practitioner about the medications that you are using.

Can Aprepatiant be co administered with other antinausea drugs?

Yes, the Aprepatante can be used together with the other anti-nausea drug, such as dexamethasone and 5-HT3 antagonists, in order to have a complete control over the nausea.