| Brand Name | Cortenema |
| Generic Name | Hydrocortisone |
| Drug Class | Rectal Corticosteroid |
| Availability | Prescription |
| Manufacturer | Pfizer |
| Indications | Mild-to-moderate ulcerative colitis (distal disease) |
| Type | Tablet |
| Doses | 100 mg rectally, nightly |
| Route | Rectal (enema, foam) |
| Side Effects | GI upset, fluid retention, mood changes, increased infection risk |
| Interactions | May interact with anticoagulants and vaccines; watch fluid retention |
| Overdose | Overdose may cause severe digestive symptoms and electrolyte imbalances. |
| Missed Dose | If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. |
| Contraindications | Systemic fungal infections, rectal bleeding, severe colitis. |
| Alternatives | Budesonide, Prednisone, Methylprednisolone |
| Co-Pay Assistance Program | Available OTC |
| Patient Assistance Program | Not available |
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
One of the corticosteroids is hydrocortisone that is used to decrease inflammation, but is administered to such diseases as arthritis, allergic reaction, skin disease and autoimmune disease like lupus.
Hydrocortisone works by the following mechanism of action: it suppresses the immune system, prevents inflammatory products in the organism and is applicable in the treatment of swelling, erythema, and pain.
The side effects are the most frequent, they include weight gain, appetite, mood and stomach irritation. It might also lead to the weakening of the bones, hypertension and vulnerability to infections in future.
Hydrocortisone is used as pills, topical either as a cream or injected, depending on the disorder to which it is applied. Take whatever and however you are instructed to take by your health care provider.
Yes, the Hydrocortisone cream or ointment is usually applied on the skin rashes, skin inflammation, eczema and any other inflammatory diseases related to the skin to reduce the edema and curb the scratching.
The drug should be taken in the case where the merits of using hydrocortisone in pregnancy exceed the demerits. And it must be accompanied by the medical provider consultation prior to pregnancy.
It can be taken immediately you recall that you can forget to take a dose but not when you are close to the moment of taking the next dose. Do not use 2 doses simultaneously as opposed to one.
Yes, Hydrocortisone can give a person permanent high blood pressure of an individual especially when taken in massive amount. Blood pressure checking also is to be checked regularly during the long-term therapy.
Yes, there is an interaction of Hydrocortisone with other medications, including the blood thinners, vaccinations, and the immunosuppressants. Do not forget to inform your health care professional about all of your medications, too.
The hydrocortisone typically works in a few hours and reduces the symptoms and downplays the inflammation. However, the full advantages must be received in a number of days, based on the condition being treated.
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