Any intended use of Lubiprostone?
Lubiprostone is indicated as an agent in the treatment of constipation, such as chronic idiopathic constipation, constipation in patients with irritable bowel syndrome (IBS-C) and constipation during opioid use.
How does Lubiprostone work?
Lubiprostone is an agent that acts by an increment in the secretions of the fluid within the intestines, which soften the stool and promote bowel movement actions.
What are most frequent side effects of Lubiprostone?
The commonity side effects are nausea, diarrhea, headache, and pain in the abdomen. Most of the side effects are mild and disappear as the use progresses.
Commentary: In what way is Lubiprostone administered?
Lubiprostone is normally administered via oral method, that is, in form of capsules. One is normally advised to chew on it with food and water to minimize the chances of nausea.
Can Lubiprostone be used for chronic constipation?
Yes, Lubiprostone has been used to treat chronic constipation including idiopathic constipation in addition to constipation as a result of IBS.
Is Lubiprostone use in pregnancy safe?
Use of lubiprostone during pregnancy should be done in cases where the risks have been overridden by the benefits it might present. Ask your medical professional to advise you in case of pregnancy.
So what was to be done in case I missed a dose of Lubiprostone?
In case of an overdose, you should resume using the dosage when you feel like, but not when you almost miss the next dosage. Do not take two doses at once.
What is the fast rate of action of Lubiprostone?
With lubiprostone, constipation normally gets relieved after 24-48 hours but in some individuals it may be relieved sooner or later.
Is there a problem of dehydration with Lubiprostone?
Lubiprostone may have a diarrhea effect which can result in dehydration. Take lots of fluids, and seek medical consultation in case the situation with diarrhea deteriorates.
Is there an interaction between Lubiprostone and other drugs?
There can be an interaction of lubiprostone with other medications especially those that influence the gastrointestinal motility. Report any medication that you are taking to your healthcare provider.
Medically Reviewed by Dr. Bharat Pothuri, MD, FACG