| Brand Name | Amitiza |
| Generic Name | Lubiprostone |
| Drug Class | Chloride Channel Activator, laxative |
| Availability | Prescription |
| Manufacturer | Takeda Pharmaceuticals |
| Indications | Chronic constipation, IBS-C |
| Type | Capsule |
| Doses | 8 mcg, 24 mcg |
| Route | Oral |
| Side Effects | Nausea, diarrhea, headache |
| Interactions | Methadone, NSAIDs |
| Overdose | Seek emergency medical help |
| Missed Dose | Take as soon as remembered |
| Contraindications | Bowel obstruction, severe diarrhea |
| Alternatives | Linaclotide, Plecanatide |
| Co-Pay Assistance Program | Available |
| Patient Assistance Program | Available |
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Lubiprostone is indicated as an agent in the treatment of constipation, such as chronic idiopathic constipation, constipation in patients with irritable bowel syndrome (IBS-C) and constipation during opioid use.
Lubiprostone is an agent that acts by an increment in the secretions of the fluid within the intestines, which soften the stool and promote bowel movement actions.
The commonity side effects are nausea, diarrhea, headache, and pain in the abdomen. Most of the side effects are mild and disappear as the use progresses.
Lubiprostone is normally administered via oral method, that is, in form of capsules. One is normally advised to chew on it with food and water to minimize the chances of nausea.
Yes, Lubiprostone has been used to treat chronic constipation including idiopathic constipation in addition to constipation as a result of IBS.
Use of lubiprostone during pregnancy should be done in cases where the risks have been overridden by the benefits it might present. Ask your medical professional to advise you in case of pregnancy.
In case of an overdose, you should resume using the dosage when you feel like, but not when you almost miss the next dosage. Do not take two doses at once.
With lubiprostone, constipation normally gets relieved after 24-48 hours but in some individuals it may be relieved sooner or later.
Lubiprostone may have a diarrhea effect which can result in dehydration. Take lots of fluids, and seek medical consultation in case the situation with diarrhea deteriorates.
There can be an interaction of lubiprostone with other medications especially those that influence the gastrointestinal motility. Report any medication that you are taking to your healthcare provider.
