| Brand Name | Amitiza |
| Generic Name | Lubiprostone |
| Drug Class | Chloride Channel Activator, laxative |
| Availability | Prescription |
| Manufacturer | Takeda Pharmaceuticals |
| Indications | Chronic constipation, IBS-C |
| Type | Capsule |
| Doses | 8 mcg, 24 mcg |
| Route | Oral |
| Side Effects | Nausea, diarrhea, headache |
| Interactions | Methadone, NSAIDs |
| Overdose | Seek emergency medical help |
| Missed Dose | Take as soon as remembered |
| Contraindications | Bowel obstruction, severe diarrhea |
| Alternatives | Linaclotide, Plecanatide |
| Co-Pay Assistance Program | Available |
| Patient Assistance Program | Available |
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Lubiprostone is used to treat constipation, including chronic idiopathic constipation, constipation associated with irritable bowel syndrome (IBS-C), and opioid-induced constipation.
Lubiprostone works by increasing fluid secretion in the intestines, which softens the stool and stimulates bowel movements.
Common side effects include nausea, diarrhea, headache, and abdominal pain. Most side effects are mild and go away with continued use.
Lubiprostone is typically taken orally in capsule form. It is usually recommended to take it with food and water to reduce the risk of nausea.
Yes, Lubiprostone is approved for treating chronic constipation, including idiopathic constipation and constipation associated with IBS.
Lubiprostone should only be used during pregnancy if the potential benefits outweigh the risks. Consult your healthcare provider for guidance if you are pregnant.
If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose. Do not take two doses at once.
Lubiprostone typically works within 24 to 48 hours to relieve constipation, though some people may experience relief sooner or later.
Lubiprostone can cause diarrhea, which may lead to dehydration. Drink plenty of fluids and consult your healthcare provider if diarrhea becomes severe.
Lubiprostone may interact with other medications, particularly those that affect gastrointestinal motility. Inform your healthcare provider of all medications you're taking.
