Eosinophilic Jejunitis is an inflammatory condition of the jejunum (the middle part of the small intestine) caused by an excessive buildup of eosinophils, a type of white blood cell. Normally these cells help fight infections, but when they accumulate in the gut lining they trigger inflammation, pain, and digestive dysfunction. Unlike eosinophilic enteritis, which may involve multiple segments of the small intestine, eosinophilic jejunitis is confined to the jejunum.
Symptoms can vary in intensity and duration. You may experience:
The exact cause is not always clear, but several factors are known to contribute:
At GastroDoxs in Cypress, our eosinophilic jejunitis specialists are committed to delivering personalized, compassionate care every step of the way. From advanced diagnostics to tailored treatment plans and ongoing nutritional support, we're here to help you regain comfort and confidence in your digestive health. Don't wait-book your consultation today and begin your journey to lasting relief.
We've successfully treated more than 1K patients, helping individuals improve their digestive health and overall well-being through expert, personalized care.
With over 20 years of experience, GastroDoxs has been a trusted provider of gastroenterology care, focusing on delivering the best outcomes for patients
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Diagnosis usually requires an upper endoscopy with biopsy of the jejunum to confirm eosinophil infiltration. Blood tests and imaging studies may also be performed to support the diagnosis and rule out other conditions.
Yes. Because Eosinophilic Jejunitis affects the small intestine (jejunum), colonoscopy findings can appear normal. An upper GI evaluation is often necessary to detect inflammation higher up.
Your doctor may recommend an elimination diet to identify trigger foods. Common culprits include dairy, wheat, soy, eggs, and nuts. A nutritionist can help you safely reintroduce foods and plan balanced meals.
There appears to be a genetic component, so a family history of eosinophilic gastrointestinal disorders or allergic diseases may increase your risk. Environmental and immune factors also play a role.
Short-term corticosteroids are effective at reducing inflammation. For long-term use, we monitor for side effects and may transition to steroid-sparing agents or biologic therapies to minimize risks.
Symptom relief varies. Some patients notice improvement within days of starting treatment, while others may require several weeks of diet modification and medication to achieve full relief.
Yes. Chronic inflammation and occasional bleeding in the small intestine can lead to iron-deficiency anemia. Iron supplements or dietary adjustments may be recommended.
There is no definitive cure, but most patients achieve good symptom control with a combination of diet changes, medications, and ongoing monitoring to prevent flares.
Any blood in the stool warrants prompt medical attention. Contact your doctor to determine the cause and adjust your treatment plan as needed.
Some patients require ongoing low-dose medication or regular dietary reviews to maintain remission. Your specialist will tailor a follow-up schedule based on your individual response and risk of relapse.
