Overlap Syndrome happens when two related diseases occur together, sharing symptoms or influencing each other. Common examples include Asthma-COPD Overlap Syndrome (ACOS) and myelodysplastic/myeloproliferative (MDS/MPN) overlap. Early diagnosis and coordinated care can prevent serious complications.
Symptoms depend on the type but often involve breathing or blood issues:
Several factors can contribute to Overlap Syndrome by promoting inflammation or genetic changes:
Our Houston team specializes in diagnosing and managing Overlap Syndrome, offering integrated care for both respiratory and blood-related conditions. From advanced lung function testing and personalized inhaler regimens to targeted therapies for blood disorders, nutritional counseling, and ongoing monitoring, we tailor every treatment plan to your unique needs. With a patient-centered approach, multidisciplinary collaboration, and a commitment to long-term relief, GastroDoxs is here to help you regain control of your health. Don't wait-book your appointment today and start your journey toward better well-being.
We've successfully treated more than 1k patients, helping individuals improve their digestive health and overall well-being through expert, personalized care.
With over 20 years of experience, GastroDoxs has been a trusted provider of gastroenterology care, focusing on delivering the best outcomes for patients
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Asthma-COPD Overlap Syndrome (ACOS) occurs when you have features of both asthma and chronic obstructive pulmonary disease. You may experience airway inflammation and reversible bronchospasm typical of asthma, along with the persistent airflow limitation seen in COPD. Treatment often combines therapies used for each condition.
Most clinicians document asthma-COPD overlap by assigning two ICD-10 codes: J44.9 for COPD, unspecified, and J45.9 for asthma, unspecified. This combination accurately reflects both diagnoses for billing and clinical record-keeping.
In some cases, overlapping myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) can evolve into acute leukemia. Early diagnosis, regular monitoring, and timely treatment help reduce this risk and improve long-term outcomes.
If you're experiencing mixed symptoms-such as persistent shortness of breath coupled with fatigue, bruising, or unexplained fevers-you should schedule an appointment with an Overlap Syndrome specialist as soon as possible.
Evaluation may include pulmonary function tests (spirometry), chest CT scans, complete blood counts, and, when blood disorders are suspected, a bone marrow biopsy. These tests help pinpoint the overlap and guide your personalized treatment plan.
Yes. Quitting smoking, following a balanced diet, maintaining a healthy weight, exercising as tolerated, and managing stress can all support your treatment and improve symptom control.
Overlap Syndrome isn't always curable, but many patients achieve excellent control of their symptoms with the right combination of medications, lifestyle adjustments, and regular monitoring.
Follow-up frequency depends on the severity and type of overlap. Typically, visits occur every 3 to 6 months to assess your symptoms, adjust treatments, and order necessary tests.
Yes. Our multidisciplinary team provides comprehensive care for both pediatric and adult patients with Overlap Syndrome, tailoring interventions to each age group's unique needs.
Before your visit, compile a list of current medications and dosages, gather any previous test results or imaging reports, and keep a symptom diary noting triggers, severity, and timing. This preparation helps us develop the most effective treatment plan.
