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Questran - Cholestyramine

Bharat Pothuri Medically Reviewed by Dr. Bharat Pothuri, MD, FACG
Brand Name
Questran
Generic Name
Cholestyramine
Drug Class
Bile Acid Sequestrant
Availability
Prescription only
Manufacturer
Bristol-Myers Squibb
Indications
Primary hypercholesterolemia (high cholesterol) Relief of pruritus (itching) associated with partial biliary obstruction Management of diarrhea associated with bile acid malabsorption
Type
Tablet
Doses
4 grams
Route
Oral
Side Effects
Constipation Bloating Gas Abdominal discomfort Nausea Heartburn Increased risk of bleeding due to vitamin K deficiency with long-term use
Interactions
Warfarin Thiazide diuretics Propranolol Digoxin Fat-soluble vitamins (A, D, E, K)
Overdose
Severe constipation Intestinal obstruction
Missed Dose
Take as soon as remembered unless it's close to the next dose
Contraindications
Complete biliary obstruction Hypersensitivity to cholestyramine or any component of the formulation
Alternatives
Other bile acid sequestrants, such as colestipol and colesevelam Statins or other lipid-lowering agents, depending on the condition being treated
Co-Pay Assistance Program
Available
Patient Assistance Program
Available

Frequently Asked Questions

What is Cholestyramine used for?

Cholestyramine is used to lower cholesterol levels and treat itching caused by certain types of liver disease by binding bile acids in the intestines.

How does Cholestyramine work?

Cholestyramine works by binding bile acids in the gut, preventing their reabsorption, and thereby lowering cholesterol levels in the bloodstream.

What are the common side effects of Cholestyramine?

Common side effects include constipation, bloating, and indigestion. Long-term use can sometimes lead to nutrient deficiencies due to reduced absorption.

How should Cholestyramine be taken?

Cholestyramine is typically taken in powder form, mixed with water. The dosage and frequency will depend on your doctor�s recommendations and your cholesterol levels.

Is Cholestyramine safe during pregnancy?

Cholestyramine is considered safe during pregnancy. However, always consult your healthcare provider before starting any new medication during pregnancy.

Can Cholestyramine cause constipation?

Yes, one of the most common side effects of Cholestyramine is constipation. Drinking plenty of fluids and increasing fiber intake can help manage this side effect.

What should I do if I miss a dose of Cholestyramine?

If you miss a dose, take it as soon as you remember unless it�s almost time for the next dose. Do not take two doses at once.

Can Cholestyramine interact with other medications?

Yes, Cholestyramine can interfere with the absorption of certain medications, including blood thinners, thyroid medications, and others. Take other medications at least 1 hour before or 4 hours after Cholestyramine.

How long does it take for Cholestyramine to work?

Cholestyramine may take several weeks to show noticeable effects in lowering cholesterol levels or reducing itching associated with liver disease.

Can Cholestyramine be used for diarrhea?

Yes, Cholestyramine can help control diarrhea by binding bile acids in the intestines, particularly in cases of bile acid malabsorption.