| Brand Name | Questran |
| Generic Name | Cholestyramine |
| Drug Class | Bile Acid Sequestrant |
| Availability | Prescription only |
| Manufacturer | Bristol-Myers Squibb |
| Indications | Primary hypercholesterolemia (high cholesterol) Relief of pruritus (itching) associated with partial biliary obstruction Management of diarrhea associated with bile acid malabsorption |
| Type | Tablet |
| Doses | 4 grams |
| Route | Oral |
| Side Effects | Constipation Bloating Gas Abdominal discomfort Nausea Heartburn Increased risk of bleeding due to vitamin K deficiency with long-term use |
| Interactions | Warfarin Thiazide diuretics Propranolol Digoxin Fat-soluble vitamins (A, D, E, K) |
| Overdose | Severe constipation Intestinal obstruction |
| Missed Dose | Take as soon as remembered unless it's close to the next dose |
| Contraindications | Complete biliary obstruction Hypersensitivity to cholestyramine or any component of the formulation |
| Alternatives | Other bile acid sequestrants, such as colestipol and colesevelam Statins or other lipid-lowering agents, depending on the condition being treated |
| Co-Pay Assistance Program | Available |
| Patient Assistance Program | Available |
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Cholestyramine is used to lower cholesterol levels and treat itching caused by certain types of liver disease by binding bile acids in the intestines.
Cholestyramine works by binding bile acids in the gut, preventing their reabsorption, and thereby lowering cholesterol levels in the bloodstream.
Common side effects include constipation, bloating, and indigestion. Long-term use can sometimes lead to nutrient deficiencies due to reduced absorption.
Cholestyramine is typically taken in powder form, mixed with water. The dosage and frequency will depend on your doctor�s recommendations and your cholesterol levels.
Cholestyramine is considered safe during pregnancy. However, always consult your healthcare provider before starting any new medication during pregnancy.
Yes, one of the most common side effects of Cholestyramine is constipation. Drinking plenty of fluids and increasing fiber intake can help manage this side effect.
If you miss a dose, take it as soon as you remember unless it�s almost time for the next dose. Do not take two doses at once.
Yes, Cholestyramine can interfere with the absorption of certain medications, including blood thinners, thyroid medications, and others. Take other medications at least 1 hour before or 4 hours after Cholestyramine.
Cholestyramine may take several weeks to show noticeable effects in lowering cholesterol levels or reducing itching associated with liver disease.
Yes, Cholestyramine can help control diarrhea by binding bile acids in the intestines, particularly in cases of bile acid malabsorption.
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