| Brand Name | Linzess |
| Generic Name | Linaclotide |
| Drug Class | Probiotic (Lactobacillus) |
| Availability | Prescription |
| Manufacturer | Ironwood Pharmaceuticals, Forest Laboratories |
| Indications | IBS-C (Chronic Constipation in IBS) |
| Type | Capsule |
| Doses | 145 mcg orally once daily (for adults); 72 mcg for pediatric use |
| Route | Oral |
| Side Effects | Diarrhea, flatulence, abdominal pain, bloating |
| Interactions | No systemic absorption; no known interactions |
| Overdose | Diarrhea, abdominal pain. |
| Missed Dose | Skip missed dose; resume next schedule. |
| Contraindications | Mechanical GI obstruction, age < 6 years |
| Alternatives | Lubiprostone, Prucalopride |
| Co-Pay Assistance Program | Available Rx |
| Patient Assistance Program | Not available |
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Linaclotide is used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) by increasing bowel movement frequency.
Linaclotide works by increasing fluid secretion in the intestines, which helps soften stools and improves bowel movement frequency.
Common side effects include diarrhea, abdominal pain, bloating, and gas.
Linaclotide should be taken on an empty stomach, at least 30 minutes before the first meal of the day.
Linaclotide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor for advice.
If you miss a dose, take it as soon as you remember unless it�s almost time for your next dose. Do not take two doses at once.
Linaclotide has minimal drug interactions, but it�s always best to inform your doctor of all medications you're taking, especially those affecting gastrointestinal function.
Linaclotide may take a few days to a week to show its full effects on relieving constipation and improving bowel function.
Linaclotide is typically used for long-term management of chronic constipation and IBS-C, but long-term use should be monitored by a healthcare provider.
If side effects like severe diarrhea or abdominal pain occur, contact your doctor immediately. Adjusting the dose or discontinuing treatment may be necessary.
