Overlap Syndrome occurs when you develop clear features of two distinct diseases at the same time. For example, you might have autoimmune hepatitis together with primary biliary cholangitis, or breathe like an asthmatic while also having COPD. Recognizing both parts of the illness is key to building the right treatment plan.
Because two conditions are involved, you may experience symptoms from more than one organ system. Typical signs include:
The exact trigger for Overlap Syndrome remains unclear, but several factors may play a role:
At GastroDoxs in Katy, our multidisciplinary team specializes in diagnosing and managing complex overlap syndromes-whether liver, lung, or rheumatic. We create personalized treatment plans, offer comprehensive testing, and provide ongoing support to help you regain control of your health. Don't wait-book your appointment today and take the first step toward clearer answers and better living.
We've successfully treated more than 1K patients, helping individuals improve their digestive health and overall well-being through expert, personalized care.
With over 20 years of experience, GastroDoxs has been a trusted provider of gastroenterology care, focusing on delivering the best outcomes for patients
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Overlap Syndrome occurs when a patient shows clear signs of two distinct diseases at the same time, such as autoimmune hepatitis plus primary biliary cholangitis or asthma combined with COPD.
Doctors diagnose liver overlap through blood tests (including liver enzymes and autoimmune panels), imaging studies like ultrasound or MRI, and sometimes liver biopsy to confirm the presence of both conditions.
Overlap syndrome means you meet the diagnostic criteria for two separate diseases, whereas mixed connective tissue disease presents symptoms that overlap multiple conditions without fully meeting the criteria for any single one.
Physicians review your medical history, perform spirometry (breathing tests) to assess airflow limitation and reversibility, and may order a chest CT scan to distinguish features of both asthma and COPD.
Yes. With a tailored treatment plan-including inhalers, lifestyle adjustments, and regular monitoring-many patients manage symptoms effectively and maintain an active life.
If you experience symptoms affecting more than one organ system-such as joint pain plus liver abnormalities or persistent cough with breathlessness-schedule an evaluation promptly.
Absolutely. Quitting smoking, following a balanced diet, exercising regularly, and managing stress can improve overall health and support medical treatments.
Surgery is uncommon. In severe liver overlap cases, a transplant may be considered, but most patients are treated successfully with medications and lifestyle interventions.
Regular follow-up every 3 to 6 months is typical, though frequency may increase based on symptom severity, medication changes, or new test results.
Most health plans cover diagnostic tests and standard treatments. Our team can assist you in verifying your benefits and navigating any insurance questions.
