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Overlap Syndrome

On GastroDoxs in Houston, there is the specialized comprehensive Overlap Syndrome assessment and treatment option where the personalized care approach is offered to patients with overlapping liver disorders combining the high-level diagnostics with the empathetic service to enhance the results and the quality of life right here in Texas.

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Houston Methodist leading Medicine
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Bharat Pothuri
Symptoms

What is Overlap Syndrome?

Overlap Syndrome is a condition that crops up in two diseases, with similar symptoms or affecting one another. The most common ones are Asthma-COPD Overlap Syndrome (ACOS) and myelodysplastic/myeloproliferative (MDS/MPN) overlap. Teen pregnancy will not result in severe problems since it is possible to avoid them early and provide care to avoid these complications.

Common Symptoms

Symptoms are associated with the type but typically include breathing or blood problems:

  • SOB / wheezing (asthma-COPD overlap)
  • Longstanding cough with excessive mucus.
  • Sedation, lack of energy, or red blood cell deficiency (MDS/MPN)
  • Low grade fevers or frequent infections.
  • Painches at the chest area or tightness.

Causes

There are various factors which may cause Overlap Syndrome by facilitating inflammation or genetic alterations:

  • Genetic predisposition in the functioning of the lungs or blood cells.
  • Permanent airways or bone marrow inflammation.
  • Smoke, pollution, or chemical irritation.
  • Zip-bow asthma or persistent pulmonary disease disease.
  • Abnormalities in bone marrow with a MDS or MPN disorder.
Treatment

Treatment Options for Overlap Syndrome in Jersey Village

Treatment includes lifestyle changes and medical care:

  • Inhalers and steroids: Bronchodilators and inhaled corticosteroids both are used to produce a shrinking of the airway inflammation and facilitate breathing.
  • Disease-specific therapeutics: To regulate the growth of abnormal blood cells MDM/MPN chemotherapy or disease-modifying agents are used.
  • Pulmonary rehabilitation: Overseen exercises and breathing methods to tough up pulmonary work and alleviate the symptoms.
  • Smoking cessation support: To help you quit smoking and protect your lungs, the program includes support to help you quit smoking by smoking cessation counseling, nicotine replacement therapies and behavior change interventions.
  • Nutritional recommendation: Specialized diets containing large amounts of anti-inflammatory nutrients and anti-oxidants to aid immunity.
  • Frequent follow-up: To follow up on disease progress, periodic lung function tests, CT scans, blood panel and bone marrow biopsies.
  • Integrated care: All-purpose management with pulmonologists, hematologists, and your primary provider to have the joint treatment plan.

Why Choose GastroDoxs?

We have a team of doctors in the city of Houston who are specialists in finding out and treating Overlap Syndrome and provide holistic care for both respiratory and blood-related disorders. From high-tech lung function testing and personalized inhaler therapies to specialized medications for blood conditions, dietary advice, and regular follow-ups, we design each treatment plan to match your individual needs. GastroDoxs practices a patient-centered approach with multidisciplinary teamwork, dedicated to long-term relief and helping you feel in control of your health. Don’t wait—book your appointment today and begin your journey toward improved well-being.

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We've successfully treated more than 3.9K patients, helping individuals improve their digestive health and overall well-being through expert, personalized care.

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With over 20 years of experience, GastroDoxs has been a trusted provider of gastroenterology care, focusing on delivering the best outcomes for patients

Bharat Pothuri

About the Author

Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.

Frequently Asked Questions

What is asthma-COPD overlap?

Asthma-COPD Overlap Syndrome occurs when a person has overlapping symptoms of both asthma and chronic obstructive pulmonary disease (COPD). You may experience airway inflammation and reversible bronchospasms typical of asthma, along with the long-term airflow limitations found in COPD. Treatment often combines therapies used for both conditions.

What is the ICD-10 code of asthma-COPD overlap?

Most clinicians use two ICD-10 codes to document asthma-COPD overlap: J44.9 for COPD (unspecified) and J45.9 for asthma (unspecified). This dual coding ensures accurate diagnosis, billing, and clinical record keeping.

Can MDS/MPN lead to leukemia?

In some cases, myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) may progress into acute leukemia. Early diagnosis, regular monitoring, and timely treatment can reduce this risk and improve long-term outcomes.

When is it necessary to visit a specialist in Houston?

If you experience mixed symptoms such as persistent shortness of breath, unexplained fatigue, bruising, or recurrent fevers, you should schedule a consultation with an Overlap Syndrome specialist as soon as possible.

What tests are used?

Diagnosis may include pulmonary function tests (spirometry), chest X-rays, complete blood counts, and, when blood disorders are suspected, bone marrow examinations. These tests help confirm the overlap and guide your personalized treatment plan.

Can lifestyle changes help?

Yes. Quitting smoking, maintaining a healthy diet, staying physically active, managing stress, and keeping a balanced body weight all support treatment success and improve symptom control.

Is there a cure for Overlap Syndrome?

While Overlap Syndrome may not be fully curable, most patients can manage their symptoms effectively through a tailored combination of medications, lifestyle changes, and routine follow-ups.

How frequently will I have to consult a physician?

The frequency of follow-ups depends on the type and severity of your condition. Generally, visits are recommended every 3–6 months to review progress, adjust treatment, and order necessary tests.

Do you deal with children with Overlap?

Yes. Our multidisciplinary team provides comprehensive care for both pediatric and adult patients with Overlap Syndrome, tailoring treatments according to age and specific needs.

What is my preparation upon my appointment?

Before your visit, prepare a list of your current medications and dosages, previous test or imaging results, and a symptom diary noting triggers, severity, and timing. This preparation helps us design the most effective treatment plan for you.

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