Alpha 1 Anti Trypsin Deficiency (AATD) is a genetic disease where the body produces insufficient of a protective protein alpha-1 antitrypsin. In the lack of sufficient amounts of this protein, in the long term, the tissues of the lungs might be damaged, and, not being able to get rid of the surplus protein, it is likely to accumulate in the liver, causing organ failure.
The initial symptoms of AATD can be unnoticed but as the disease advances you would find:
AATD is brought about by a genetic mutation of SERPINA1 gene. Key points include:
We are GastroDoxs, a clinic in Jersey Village specializing in complex Alpha -1 anti trypsin deficiency therapy, which includes not only a high level of diagnostics but also a treatment plan and the continuation of both lung and liver health. Our multidisciplinary team-gastroenterologists, pulmonologists, nurses, and dietitians have work together to provide caring evidence-based care to your unique needs. Augmentation therapy and breathing support, nutritional advice and lifestyle coaching, we are determined to make you Asian American and breathe easier, have a healthy liver, and live your best life.
Ready to take the next step? Make an appointment in GastroDoxs in Jersey Village and begin your own solo AATD treatment plan.
We've successfully treated more than 1.5K patients, helping individuals improve their digestive health and overall well-being through expert, personalized care.
With over 20 years of experience, GastroDoxs has been a trusted provider of gastroenterology care, focusing on delivering the best outcomes for patients
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
The diagnosis of AATD is performed by carrying out blood screening of levels of alpha -1 antitrypsin protein and genetic analysis of the mutation of SERPINA1 gene.
Yes. Other people can only display liver related problems like raised liver enzymes or jaundice without developing symptoms with the lungs.
The therapeutic remedies comprise augmentation therapy (protein replacement), pulmonary rehabilitation, frequent liver checking, and supporting therapeutic care to handle complications.
Although AATD may cause severe lung and liver disease, timely diagnosis and concomitant intervention have improved the quality of life of many patients.
Yes. The smoking of AATD increases the rate at which the lung tissue is damaged and as such, cessation is among the most significant measures you can undertake to guard your lungs.
Eat a healthy diet, stay away from smoke and other environmental pollutants, do light workouts, keep on top of the vaccinations, and adhere to your care plan.
Yes. Family members including children can have genetic screening to detect AATD early enough and commence monitoring or treatment when necessary.
No. Some patients might develop liver disease (cirrhosis, fibrosis), whereas others could get off with pulmonary problems or stay without symptoms over a long period of time.
Visits with specialists are usually advised on a 6-12 month basis, or more often when lung and liver examination show signs of deterioration.
The Alpha-1 Antitrypsin Deficiency will need contacting GastroDoxs in Jersey Village to make an appointment with a multidisciplinary team that has experience in diagnosing and treating this illness.
