1.9K Reviews    |    4.7 Star Rating    |    20+ years of experience    |    72k+ Patients Treated

Eosinophilic Jejunitis

Explore the Gastro Clinic's comprehensive guide on eosinophilic gastroenteritis to learn about its symptoms, causes, diagnostic methods, and treatment options. This reliable resource offers expert insights, management strategies, and tips for improving gastrointestinal health through diet, medication, and clinical care.

Call Us 832-632-4070 Schedule Now Click Here Text Us 832-632-4070 Learn More Click Here
Texas Medical Board
Harris County Medical Society
American College of Gastroenterology
American Society for Gastrointestinal Endoscopy
Memorial hermann
Houston Methodist leading Medicine
HCA Houston Healthcare
Nghia Nguyen

About the Expert

Dr. Nghia Nguyen, DO, is a board-certified gastroenterologist providing advanced digestive care in the Greater Houston area. He earned his medical degree from the Texas College of Osteopathic Medicine and completed both his Internal Medicine residency and Gastroenterology fellowship at the University of Texas at Rio Grande Valley. Dr. Nguyen specializes in treating conditions such as acid reflux, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and liver disorders.

Common Causes and Risk Factors

  • Food allergies (dairy, soy, wheat, eggs, shellfish)
  • Personal or family history of atopy (asthma, eczema, allergic rhinitis)
  • Autoimmune disorders and dysregulated immune response
  • Environmental allergens (pollen, mold, dust mites)
  • Prior gastrointestinal infections or chronic irritation
  • Idiopathic eosinophil‐driven inflammation

Signs and Symptoms

  • Recurrent abdominal pain or cramping
  • Nausea, vomiting or early satiety
  • Diarrhea or bulky, loose stools
  • Bloating, gas and fullness
  • Unintentional weight loss and poor growth (in children)
  • Signs of malabsorption (fatigue, nutrient deficiencies)

How Dr. Nghia Nguyen Diagnoses Eosinophilic Jejunitis?

Dr. Nguyen uses a step-by-step approach:

Medical History and Physical Exam

He reviews your symptom pattern—especially epigastric pain—food triggers, allergy history, and any prior GI issues.

Blood Tests

Complete blood count checks for elevated eosinophils and rules out other causes of inflammation.

Endoscopic Evaluation

  • Upper endoscopy visualizes the duodenum and proximal jejunum for swelling or mucosal changes.
  • Balloon-assisted enteroscopy may be used to reach deeper segments if needed.

Tissue Biopsy

Multiple biopsy samples from the jejunal wall are examined microscopically to confirm eosinophil infiltration.

Allergy and Immunology Testing

Skin-prick or serum IgE panels help identify food or environmental allergens contributing to your symptoms.

Dr. Nghia Nguyen
Treatment

Our Team offers comprehensive treatment options for eosinophilic jejunitis.

1. Diet and Nutritional Management

  • Customized elimination or elemental diets to identify and remove trigger foods
  • Supervised reintroduction of safe foods under dietitian guidance
  • Enteral nutrition support when malabsorption or weight loss is severe

2. Medications

  • Oral corticosteroids (e.g., prednisone) for rapid control of inflammation
  • Topical steroids (e.g., budesonide) to target the jejunum with fewer systemic effects
  • Leukotriene antagonists or mast cell stabilizers for long-term symptom management
  • Biologic therapies or immunomodulators in select, refractory cases

3. Minimally Invasive or Advanced Procedures

  • Endoscopic balloon dilation for intestinal strictures caused by scarring
  • FibroScan or imaging follow-up to monitor intestinal wall thickness
  • Enrollment in clinical trials investigating novel biologics or dietary therapies
Dr Nghia Nguyen

About the Author

Dr. Nghia Nguyen, DO, is a board-certified gastroenterologist providing advanced digestive care in the Greater Houston area. He earned his medical degree from the Texas College of Osteopathic Medicine and completed both his Internal Medicine residency and Gastroenterology fellowship at the University of Texas at Rio Grande Valley. Dr. Nguyen specializes in treating conditions such as acid reflux, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and liver disorders.

Frequently Asked Questions

What is eosinophilic jejunitis?

Eosinophilic jejunitis is a rare disorder in which eosinophils, a type of white blood cell, accumulate in the jejunum (middle portion of the small intestine), leading to inflammation and digestive problems.

What are the symptoms?

Common symptoms include belly pain or cramps, nausea or vomiting, diarrhea or loose stools, bloating or gas, and unintentional weight loss.

How is it diagnosed?

Diagnosis involves a review of your medical history, blood tests to measure eosinophil levels, an endoscopy to visualize the small intestine, and a biopsy of intestinal tissue for confirmation.

How is it treated?

Treatment typically includes an elimination diet guided by a dietitian, medications such as steroids or leukotriene blockers, allergy medicines if needed, and occasional balloon dilation to relieve strictures.

What causes eosinophilic jejunitis?

Although the exact cause is unknown, common triggers include food allergies (e.g., milk, soy, wheat), a family history of allergies or asthma, autoimmune factors, and environmental allergens like pollen or mold.

Can diet changes help?

Yes. An elimination diet can identify and remove trigger foods, and a structured reintroduction plan helps establish a safe, balanced diet that reduces symptoms.

Is eosinophilic jejunitis common in Houston?

No, it's rare, but Dr. Nguyen at GastroDoxs sees and treats many patients from across the Houston area using the latest protocols and personalized care plans.

Related Blogs
Abdominal Pain

Here's When to Seek Help for Diarrhea

Read More
Abdominal Pain

What Your Diarrhea May Be Signaling

Read More
Abdominal Pain

Does Diarrhea Require a Medical Evaluation?

Read More