1.9K Reviews    |    4.7 Star Rating    |    20+ years of experience    |    72k+ Patients Treated

Eosinophilic Jejunitis

Eosinophilic jejunitis is a rare inflammatory disorder of the small intestine where excessive eosinophils collect in the jejunum, causing pain, bloating, and digestive issues. At GastroDoxs in Houston, Dr. Bharat Pothuri offers expert diagnosis and personalized treatments for lasting relief.

Call Us 832-632-4070 Schedule Now Click Here Text Us 832-632-4070 Learn More Click Here
Texas Medical Board
Harris County Medical Society
American College of Gastroenterology
American Society for Gastrointestinal Endoscopy
Memorial hermann
Houston Methodist leading Medicine
HCA Houston Healthcare
Bharat Pothuri

About the Expert

Dr. Bharat Pothuri is a board-certified gastroenterologist and the founder of GastroDoxs. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.

What Is Eosinophilic Jejunitis?

Eosinophilic jejunitis is a rare inflammatory condition in which eosinophils-a type of white blood cell-accumulate in the jejunum (the middle segment of the small intestine). This buildup leads to swelling, pain, and impaired digestion. Early recognition and tailored management can help restore gut health and reduce symptoms.

Common Causes and Risk Factors

  • Food allergies (dairy, wheat, soy, nuts, eggs)
  • Environmental allergies (pollen, dust mites)
  • Overactive immune response sending excess eosinophils to the gut
  • Family history of eosinophilic gastrointestinal disorders
  • Coexisting allergic conditions (asthma, eczema, allergic rhinitis)

Signs and Symptoms

  • Abdominal pain or cramps, especially after meals
  • Bloating and excessive gas
  • Diarrhea or loose, frequent stools
  • Nausea and vomiting
  • Unintentional weight loss
  • Chronic fatigue or lack of energy

Expert Treatment for Eosinophilic Jejunitis by Dr. Bharat Pothuri

Dr. Pothuri uses a step-by-step approach:

Medical History and Physical Exam

He reviews your epigastric pain, bowel habits, diet, allergy history and any family history of eosinophilic disorders.

Blood Tests

We draw a complete blood count to look for elevated eosinophils, assess inflammatory markers and rule out parasitic infections.

Stool Studies

Stool analysis checks for infectious agents, parasites and markers of gut inflammation.

Endoscopy with Biopsy

An upper endoscopy or enteroscopy allows Dr. Pothuri to visualize the jejunum directly and take tissue samples. Pathology confirms eosinophil infiltration.

Imaging Studies

  • CT or MR enterography evaluates small-bowel wall thickening, edema and motility changes.
  • Abdominal ultrasound can detect bowel wall abnormalities and guide further testing.

Advanced and Allergy Testing (if needed)

Allergy panels or elimination diets identify food triggers. Capsule endoscopy may be used to survey deeper sections of the small intestine.

Dr. Bharat Pothuri
Treatment

Our Team offers a full range of care for eosinophilic jejunitis.

1. Lifestyle and Diet Modifications

  • Elimination diet: remove common triggers such as dairy, wheat, soy, nuts, and eggs
  • Food diary: track meals and symptoms to identify specific food sensitivities
  • Hydration support: drink plenty of water to aid digestion
  • Stress reduction: practice deep breathing, mindfulness, or gentle yoga

2. Medications

  • Short-course steroids to rapidly reduce intestinal inflammation
  • Coated steroids designed to deliver medicine directly to the small intestine
  • Biologics targeting eosinophil activity to prevent cell buildup
  • Acid-blocking agents (PPIs) if acid reflux contributes to symptoms

3. Minimally Invasive or Advanced Procedures

  • Balloon dilation to gently open narrowed sections of the jejunum
  • Endoscopic ultrasound for detailed imaging and guided intervention
1K

Patients Treated

Dr. Pothuri has treated more than 1K patients, helping individuals improve their digestive health and overall well-being through expert, personalized care.

20Y

Years of Experience

With over 20 years of experience, GastroDoxs has been a trusted provider of gastroenterology care, focusing on delivering the best outcomes for patients

Bharat Pothuri

About the Author

Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.

Frequently Asked Questions

What is eosinophilic jejunitis? Can it be cured?

Eosinophilic jejunitis is inflammation of the middle small intestine (jejunum) caused by too many eosinophils. While there's no single cure, most patients experience significant relief with personalized diet changes, medications, and ongoing care from Dr. Pothuri.

Can jejunitis cause bloating and diarrhea?

Yes. Eosinophil-driven swelling in the jejunum often leads to gas, bloating, and loose stools. Targeted treatment reduces inflammation and eases these symptoms.

How does Dr. Pothuri diagnose and treat eosinophilic jejunitis?

He combines a detailed history with blood and stool tests, then confirms diagnosis via endoscopy with biopsy. Treatment begins with an elimination diet and may include steroids, coated steroids, biologics, acid blockers, or minimally invasive procedures as needed.

Where can I get a biopsy for eosinophilic jejunitis in Houston?

Dr. Pothuri performs endoscopic biopsies at leading Houston centers, including Texas Medical Center, Memorial Hermann, and HCA Houston Healthcare. Our staff assists with scheduling and preparation to ensure a smooth experience.

What foods should I avoid?

Common triggers include dairy, wheat, soy, nuts, eggs, and certain fruits. An elimination diet combined with a food diary helps pinpoint your personal triggers under Dr. Pothuri's guidance.

Is long-term steroid use safe?

Dr. Pothuri minimizes systemic steroid exposure by using short courses, gut-targeted coated steroids, or biologics when possible. He closely monitors treatment to maintain safety and effectiveness.

Related Blogs
Abdominal Pain

Here's When to Seek Help for Diarrhea

Read More
Abdominal Pain

What Your Diarrhea May Be Signaling

Read More
Abdominal Pain

Does Diarrhea Require a Medical Evaluation?

Read More