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Overlap Syndrome

At GastroDoxs in Cypress, our specialized Overlap Syndrome evaluation combines advanced diagnostic testing and personalized treatment plans to address coexisting gastrointestinal and autoimmune conditions, ensuring patients in the local community receive comprehensive, compassionate care tailored to their unique health needs.

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Harris County Medical Society
American College of Gastroenterology
American Society for Gastrointestinal Endoscopy
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Houston Methodist leading Medicine
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Bharat Pothuri
Symptoms

What is Overlap Syndrome?

Overlap Syndrome is a respiratory condition in which you exhibit features of both asthma and chronic obstructive pulmonary disease (COPD). Asthma causes airway inflammation and bronchial hyper-reactivity, while COPD leads to progressive airflow obstruction. When both occur together, breathing becomes more difficult and flare-ups are more frequent. Early recognition and treatment can improve quality of life and reduce complications.

Common Symptoms

Patients with Overlap Syndrome often experience a mix of asthma and COPD signs, such as:

  • Wheezing or noisy breathing
  • Chronic cough (with or without mucus)
  • Shortness of breath during everyday activities
  • Chest tightness, often worse at night or early morning
  • Frequent exacerbations requiring additional medication

Causes

Several factors can increase the risk of developing Overlap Syndrome:

  • Long-term cigarette smoking
  • Exposure to air pollution or occupational dust and chemicals
  • A history of asthma beginning in childhood or early adulthood
  • Family history of asthma, COPD, or other lung diseases
  • Repeated respiratory infections that damage airways
Treatment

Treatment Options for Overlap Syndrome in Cypress

Treatment may include medical therapies and ongoing monitoring:

  • Steroids: Prednisone or a similar corticosteroid to calm liver inflammation.
  • Ursodeoxycholic acid: Helps improve bile flow and protects liver cells.
  • Immunosuppressants: Azathioprine or mycophenolate to regulate the immune system.
  • Methotrexate or other medications: Additional therapies if first-line drugs aren't enough.
  • Regular blood tests: Monitoring liver enzymes (ALT, AST), bilirubin, and autoantibodies to guide treatment adjustments.
  • Liver imaging and scans: Ultrasound, MRI, or elastography to track liver health and detect early fibrosis or cirrhosis.

Why Choose GastroDoxs?

At GastroDoxs in Cypress, our patient?centered focus and deep expertise in autoimmune liver disorders ensure you get the comprehensive care you need for Overlap Syndrome. From advanced diagnostics and personalized treatment plans to close collaboration with rheumatologists and hepatologists, we guide you every step of the way. Don't let overlapping conditions hold you back-book your appointment today to start your tailored journey toward better liver health and lasting relief.

1K

Patients Treated

We've successfully treated more than 1K patients, helping individuals improve their digestive health and overall well-being through expert, personalized care.

20Y

Years of Experience

With over 20 years of experience, GastroDoxs has been a trusted provider of gastroenterology care, focusing on delivering the best outcomes for patients

Bharat Pothuri

About the Author

Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.

Frequently Asked Questions

What causes overlap syndrome?

Overlap syndrome may be triggered by genetic predisposition, infections, environmental toxins, or immune system errors that cause two autoimmune liver diseases to occur together.

How is it diagnosed?

Diagnosis typically involves blood tests to check liver enzymes and antibodies, imaging studies such as ultrasound or MRI, and sometimes a liver biopsy to confirm overlapping features.

Is there a cure?

There is no definitive cure for overlap syndrome, but early and appropriate treatment can control symptoms, reduce inflammation, and protect liver function.

Do I need to change my diet?

Yes. A balanced diet that's low in unhealthy fats, rich in fiber, and tailored to liver health can support treatment and overall well-being.

How often do I need checkups?

Most patients with overlap syndrome have follow-up visits every three to six months for blood tests, liver scans, and treatment adjustments.

Is this the same as MCTD?

No. Mixed connective tissue disease (MCTD) primarily affects connective tissues throughout the body, while overlap syndrome involves two concurrent autoimmune liver conditions.

What's the outlook?

With timely diagnosis and proper management, many people with overlap syndrome live healthy, full lives. Regular monitoring helps prevent serious liver damage.

Can kids get overlap syndrome?

Yes, overlap syndrome can occur in children, although it is less common. Pediatric evaluation and specialized care are important for young patients.

Will I need a liver transplant?

A liver transplant is only necessary in severe cases where disease progression cannot be controlled and irreversible liver damage has occurred.

Are support groups available?

Yes. Your healthcare team or local hospital can connect you with support groups and resources for people living with autoimmune liver diseases.

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