Hereditary pancreatitis is a rare, inherited form of pancreatitis caused by genetic mutations (commonly PRSS1, SPINK1 or CFTR). These mutations lead to repeated bouts of pancreatic inflammation, often beginning in childhood or adolescence. Over time, recurring flare-ups can damage the pancreas and affect its ability to function.
Symptoms may start early and can include:
The primary drivers of hereditary pancreatitis are genetic, often compounded by lifestyle or environmental triggers:
At GastroDoxs in Cypress, our patient-centered approach combines expert in-office genetic testing, personalized nutrition plans, and advanced therapeutic options to help you manage hereditary pancreatitis effectively. Ready to take control of your health? Book an Appointment Today and start your journey toward long-term relief.
We've successfully treated more than 1K patients, helping individuals improve their digestive health and overall well-being through expert, personalized care.
With over 20 years of experience, GastroDoxs has been a trusted provider of gastroenterology care, focusing on delivering the best outcomes for patients
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Hereditary pancreatitis is a genetic disorder that causes repeated inflammation of the pancreas, often beginning in childhood or early adulthood and running in families.
The PRSS1 gene produces an enzyme precursor in the pancreas; certain mutations can activate these enzymes prematurely, damaging pancreatic tissue.
Hereditary pancreatitis is inherited and typically starts earlier in life, while chronic pancreatitis usually develops later and is often linked to alcohol use or gallstones.
There is no cure, but treatment focuses on managing pain, preventing complications, and supporting digestion to improve quality of life.
Surgery is considered if medical and nutritional therapies fail-that may include draining fluid collections or removing damaged portions of the pancreas.
No. Pancreas transplants are rare and reserved for the most severe cases where other treatments have not succeeded.
Yes. A gastroenterologist or pancreatic specialist provides the targeted expertise needed for long-term management and monitoring.
Yes. Genetic testing confirms the diagnosis, identifies the specific mutation, and helps guide personalized treatment plans.
Adopting a low-fat diet, avoiding alcohol and smoking, staying hydrated, and following enzyme replacement guidelines can reduce symptoms.
Yes. Symptoms often begin in childhood or adolescence, so early evaluation and family history are important for diagnosis and care.
