Eosinophilic Duodenitis occurs when an excessive number of eosinophils (a type of white blood cell) collect in the duodenum, the first part of your small intestine. These cells trigger irritation and inflammation, leading to digestive discomfort and other symptoms. A gastroenterologist will confirm the diagnosis through an endoscopy and tissue biopsy.
Symptoms can vary day to day, but many people experience:
While the exact cause isn't always clear, several factors may contribute:
At GastroDoxs in Houston, our GI specialists are uniquely trained in diagnosing and treating eosinophilic duodenitis. We combine advanced diagnostics, personalized treatment plans, and compassionate care to help you manage symptoms and regain comfort. Ready to find relief? Book your appointment today and take the first step toward better digestive health.
We've successfully treated more than 1k patients, helping individuals improve their digestive health and overall well-being through expert, personalized care.
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Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Diagnosis typically involves an upper endoscopy to examine the duodenal lining, followed by a tissue biopsy. Pathologists look for an elevated eosinophil count in the duodenal samples to confirm the condition.
The ICD-10 code used for Eosinophilic Duodenitis (classified under noninfective gastroenteritis and colitis) is K52.89.
Food allergies are a common trigger-dairy, wheat, eggs and soy often play a role-but other factors like immune dysregulation, family history, or environmental allergens can also contribute.
Yes. Eosinophilic Duodenitis affects both children and adults. In pediatric cases, symptoms may include nausea, vomiting, abdominal pain and poor growth; early evaluation by a pediatric GI specialist is important.
There is no definitive cure yet, but many patients achieve lasting symptom relief through a combination of dietary management, acid-reducing medications (PPIs), corticosteroids and newer targeted therapies.
An elimination diet helps identify and remove trigger foods-common offenders include milk, wheat, eggs, nuts and soy. Work with your GI doctor or dietitian to ensure adequate nutrition while avoiding allergens.
Beyond standard PPIs and steroids, emerging therapies such as anti-siglec-8 antibodies are under study. Patients may also qualify for clinical trials offering cutting-edge treatments.
Response times vary: some patients notice improvement within a few weeks of diet changes and medication, while others may need several months of adjustments before significant relief.
You should consult a gastroenterologist if you experience persistent abdominal pain, unexplained weight loss, chronic nausea or diarrhea, or if over-the-counter remedies don't help.
Yes. Stress can trigger or amplify gut inflammation and symptoms. Incorporating relaxation techniques, mindfulness or counseling into your care plan can help reduce flares.
