Cystic Fibrosis (CF) is a genetic disorder caused by mutations in the CFTR gene. It leads to the production of thick, sticky mucus that can clog the lungs, digestive tract, and other organs. About 1 in 3,500 babies in the U.S. is born with CF. With modern treatments, many people now live into their 40s or longer. CFTR gene changes also disrupt protein folding and can alter amino acid balance within cells.
CF symptoms often appear in early childhood. Watch for:
Cystic Fibrosis is inherited in an autosomal recessive pattern, meaning a child must inherit a faulty CFTR gene from each parent. These gene mutations result in:
At GastroDoxs, our Houston-based cystic fibrosis specialists deliver comprehensive, patient-centered care for both lung and digestive health. From advanced CFTR modulators and airway clearance techniques to targeted enzyme replacement and personalized nutrition plans, we tailor every treatment to your needs. Book your appointment today to start your journey toward better breathing and improved quality of life.
We've successfully treated more than 1k patients, helping individuals improve their digestive health and overall well-being through expert, personalized care.
With over 20 years of experience, GastroDoxs has been a trusted provider of gastroenterology care, focusing on delivering the best outcomes for patients
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Cystic Fibrosis is an inherited genetic disorder caused by mutations in the CFTR gene. It leads to the production of thick, sticky mucus that can clog the lungs and obstruct the digestive tract, resulting in respiratory infections and difficulty absorbing nutrients.
In the United States, CF affects approximately 1 in every 3,500 newborns. It is one of the most common life-shortening genetic conditions among people of European descent.
Thanks to advances in treatment and multidisciplinary care, many people with CF now live into their 40s or beyond. Life expectancy continues to improve as new therapies and personalized care plans become available.
Mutations in the CFTR gene disrupt the proper folding and function of the CFTR protein. Misfolded proteins can alter cellular amino acid balance and impair ion transport, contributing to the thick mucus and organ dysfunction seen in CF.
CF is diagnosed through a combination of a sweat chloride test, which measures salt levels in sweat, and genetic testing to identify mutations in the CFTR gene. Newborn screening programs also help detect CF early in many states.
Cystic Fibrosis is caused by inheriting two faulty copies of the CFTR gene-one from each parent. Carriers with only one defective gene typically do not show symptoms but can pass the mutation to their children.
Treatment strategies include CFTR modulators (e.g., ivacaftor, lumacaftor) to correct protein function, airway clearance techniques, inhaled medications to thin mucus and open airways, pancreatic enzyme supplements for digestion, high-calorie nutritional support, and routine vaccinations.
Yes. Gastroenterologists play a crucial role in addressing CF-related digestive issues such as malabsorption, pancreatic insufficiency, liver disease, and nutritional deficiencies. At GastroDoxs, our specialists collaborate with pulmonologists and geneticists to provide comprehensive CF care.
You should consult a CF specialist if you or your child experience persistent coughing or wheezing, recurrent lung infections, poor weight gain despite adequate appetite, greasy stools, or a family history of CF. Early intervention can improve outcomes.
To schedule an appointment with our Houston CF care team, call our office directly or use the online booking form on the GastroDoxs website. We'll work with you to develop a personalized treatment plan for better breathing and improved quality of life.
