Purinethol|Mercaptopurine

Purinethol - Mercaptopurine

Medically Reviewed by Dr. Bharat Pothuri, MD, FACG

Brand Name: Purinethol
Generic Name: Mercaptopurine
Drug Class: Antimetabolite, Immunosuppressant
Availability: Prescription only
Manufacturer: Burroughs Wellcome
Indications: Acute lymphocytic leukemia (ALL) Crohn's disease Ulcerative colitis
Type: Tablet
Doses: as directed by your healthcare provider
Route: Oral
Side Effects: Bone marrow suppression (leading to anemia, leukopenia, thrombocytopenia) Liver toxicity Nausea Vomiting Loss of appetite Increased susceptibility to infections
Interactions: Allopurinol, Warfarin Live vaccines
Overdose: Severe bone marrow suppression Bleeding Infections Gastrointestinal disturbances
Missed Dose: Take as soon as remembered unless it's close to the next dose
Contraindications: Should not be used in patients who have a hypersensitivity to mercaptopurine or any component of the formulation
Alternatives: Azathioprine (Imuran) Methotrexate Biologic agents (e.g., infliximab, adalimumab)
Co-Pay Assistance Program: Available
Patient Assistance Program: Available

Frequently Asked Questions

What is Mercaptopurine used for?

Mercaptopurine is used to treat leukemia and other cancers, as well as autoimmune conditions like Crohnï¿½s disease and ulcerative colitis by suppressing the immune system.

How does Mercaptopurine work?

Mercaptopurine works by inhibiting the production of DNA in rapidly dividing cells, including cancer cells and immune cells, thus reducing inflammation in autoimmune diseases.

What are the common side effects of Mercaptopurine?

Common side effects include nausea, vomiting, fatigue, and increased risk of infections. Serious side effects can include liver toxicity and bone marrow suppression.

How should Mercaptopurine be taken?

Mercaptopurine is typically taken orally in tablet form. The dosage is adjusted based on the condition being treated and your doctorï¿½s recommendations.

Can Mercaptopurine cause liver damage?

Yes, Mercaptopurine can cause liver toxicity. Regular liver function tests are recommended during treatment to monitor for any liver damage.

Is Mercaptopurine safe during pregnancy?

Mercaptopurine should not be used during pregnancy unless absolutely necessary. It may harm the fetus, so always consult your doctor if you are pregnant or planning to become pregnant.

What should I do if I miss a dose of Mercaptopurine?

If you miss a dose, take it as soon as you remember unless itï¿½s almost time for the next dose. Do not take two doses at once.

Can Mercaptopurine interact with other medications?

Yes, Mercaptopurine can interact with other medications, especially those that suppress the immune system or affect liver function. Always inform your doctor about all medications you're taking.

How long does it take for Mercaptopurine to work?

It may take several weeks to months for Mercaptopurine to show significant effects, especially when used to treat autoimmune diseases like Crohn's disease.

Can Mercaptopurine cause bone marrow suppression?

Yes, Mercaptopurine can cause bone marrow suppression, leading to decreased production of blood cells. Regular blood tests are essential during treatment.

Purinethol