| Brand Name | Purinethol |
| Generic Name | Mercaptopurine |
| Drug Class | Antimetabolite, Immunosuppressant |
| Availability | Prescription only |
| Manufacturer | Burroughs Wellcome |
| Indications | Acute lymphocytic leukemia (ALL) Crohn's disease Ulcerative colitis |
| Type | Tablet |
| Doses | as directed by your healthcare provider |
| Route | Oral |
| Side Effects | Bone marrow suppression (leading to anemia, leukopenia, thrombocytopenia) Liver toxicity Nausea Vomiting Loss of appetite Increased susceptibility to infections |
| Interactions | Allopurinol, Warfarin Live vaccines |
| Overdose | Severe bone marrow suppression Bleeding Infections Gastrointestinal disturbances |
| Missed Dose | Take as soon as remembered unless it's close to the next dose |
| Contraindications | Should not be used in patients who have a hypersensitivity to mercaptopurine or any component of the formulation |
| Alternatives | Azathioprine (Imuran) Methotrexate Biologic agents (e.g., infliximab, adalimumab) |
| Co-Pay Assistance Program | Available |
| Patient Assistance Program | Available |
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Mercaptopurine is used to treat leukemia and other cancers, as well as autoimmune conditions like Crohn�s disease and ulcerative colitis by suppressing the immune system.
Mercaptopurine works by inhibiting the production of DNA in rapidly dividing cells, including cancer cells and immune cells, thus reducing inflammation in autoimmune diseases.
Common side effects include nausea, vomiting, fatigue, and increased risk of infections. Serious side effects can include liver toxicity and bone marrow suppression.
Mercaptopurine is typically taken orally in tablet form. The dosage is adjusted based on the condition being treated and your doctor�s recommendations.
Yes, Mercaptopurine can cause liver toxicity. Regular liver function tests are recommended during treatment to monitor for any liver damage.
Mercaptopurine should not be used during pregnancy unless absolutely necessary. It may harm the fetus, so always consult your doctor if you are pregnant or planning to become pregnant.
If you miss a dose, take it as soon as you remember unless it�s almost time for the next dose. Do not take two doses at once.
Yes, Mercaptopurine can interact with other medications, especially those that suppress the immune system or affect liver function. Always inform your doctor about all medications you're taking.
It may take several weeks to months for Mercaptopurine to show significant effects, especially when used to treat autoimmune diseases like Crohn's disease.
Yes, Mercaptopurine can cause bone marrow suppression, leading to decreased production of blood cells. Regular blood tests are essential during treatment.
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