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Primary Sclerosing Cholangitis

Our team of hepatologists at GastroDoxs in Jersey village provides their patients with kind diagnosis and modern treatment services of the Primary Sclerosing Cholangitis, and take them through an individual care plan with the latest technologies and locally available expertise, thus ensuring the patients of our community live with a better liver.

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Harris County Medical Society
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Bharat Pothuri
Symptoms

What Is Primary Sclerosing Cholangitis?

Primary Sclerosing Cholangitis (PSC) is a chronic condition of the liver whereby bile ducts within and without the liver are inflamed, scarred and constricted. Blocking the free flow of bile with time results in a progressive liver damage, cirrhosis and problems like bile duct infection or liver failure. PSC is notably related to inflammatory bowel disease especially ulcerative colitis although it may be independent.

Common Symptoms

PSC may progress slowly, and early on you might not notice any signs. As the disease advances, watch for:

  • Persistent fatigue or low energy
  • Itchy skin (pruritus), especially at night
  • Yellowing of the skin and eyes (jaundice)
  • Pain or discomfort in the upper right abdomen
  • Dark urine or pale, clay-colored stools
  • Unintended weight loss or loss of appetite

Causes

The exact cause of PSC is not fully understood, but several factors appear to play a role:

  • Autoimmune reaction: The body's immune system mistakenly attacks its own bile ducts.
  • Genetic predisposition: Certain genes (for example, HLA-B27) may increase susceptibility.
  • Inflammatory bowel disease (IBD): Up to 70% of PSC patients also have ulcerative colitis or Crohn's disease.
  • Environmental triggers: Infections, toxins, or other exposures may initiate or worsen bile duct injury.
Treatment

Treatment Options for Primary Sclerosing Cholangitis in Jersey Village

Treatment includes medical therapies and procedural interventions:

  • Ursodeoxycholic acid (UDCA): This assists in increasing the flow of bile and it might also reduce liver enzyme concentrations.
  • Anti-inflammatory / immunosuppressants: Corticosteroids, azathioprine, or methotrexate to help with duct inflammation.
  • Endoscopic maneuver (ERCP): Widening and placing of dilated bile ducts to ensure bile is drained.
  • Pruritus treatment: Treatments, such as cholestyramine, rifampin, or antihistamines to treat itching.
  • Periodic monitoring: Periodic blood test (alkaline phosphatase, AST/ALT), imaging (MRCP or ultrasound) to monitor the course of the disease.
  • Liver transplant assessment: In patients who are fibrotic and those whose cirrhosis or other complications are not responding to other therapies.

Why Choose GastroDoxs?

It is our Jersey Village team of primary sclerosing cholangitis care-company that will cater to your needs in care provision; our professionals provide diagnostics, custom-made treatment regimens, and follow-up all under a single roof. Since the high-tech imaging (MRCP/ERCP) to the medical treatment and transplant coordination, we will be willing to maintain your liver functioning and to enhance your life quality.

Ready to Take the Next Step?

Wait no longer to protect your liver. Book your appointment with our board certified Gastroenterologist of GastroDoxs in Jersey Village today, and receive the attentive, caring treatment that you are entitled to.

286

Patients Treated

We've successfully treated more than 286 patients, helping individuals improve their digestive health and overall well-being through expert, personalized care.

20Y

Years of Experience

With over 20 years of experience, GastroDoxs has been a trusted provider of gastroenterology care, focusing on delivering the best outcomes for patients

Bharat Pothuri

About the Author

Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.

Frequently Asked Questions

What are the differences between primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC)?

Both PSC and PBC are chronic bile duct liver diseases. PSC leads to inflammation and scarring of large and small ducts and occurs more frequently in men, whereas PBC mainly attacks small intrahepatic ducts.

Is PSC and ulcerative colitis co-morbid?

Yes. Ulcerative colitis is also linked with PSC and is prevalent in nearly 70 percent of the patients, so the conditions have to be screened and monitored.

Is PSC inherited?

PSC does not come directly from your genes, but some genetic elements like HLA-B27 may predispose you. An autoimmune family history could also be a contributing factor.

How is PSC diagnosed?

PSC is characterized by abnormal liver function tests, serologic studies, and imaging examinations, such as MRCP or ERCP, which help detect constriction and scarring of the bile ducts.

Radiology PSC: What does radiology show?

Radiologic tests (MRCP or ERCP) show strictures, beading, and dilatation of bile ducts, which are used to confirm PSC and monitor the disease process.

How is PSC treated?

Treatment involves ursodeoxycholic acid to enhance bile flow, endoscopic dilation (ERCP) of strictures, immunosuppressive or anti-inflammatory medications, and liver transplant in advanced stages.

Is a change in lifestyle beneficial in the management of PSC?

Yes. By refraining from alcohol, maintaining a balanced diet, engaging in regular physical activities, and having prescribed vaccinations, liver health and wellness can be maintained.

What is the frequency of visiting a PSC specialist?

Follow-up typically occurs every 6-12 months, but more frequent visits might be required in cases of symptom progression or complications.

How is PSC doing in the long-term perspective?

PSC progresses slowly. Early diagnosis and proper treatment can maintain liver function, improve quality of life, and delay complications.

What is the nearest Jersey Village PSC specialist?

In Jersey Village, GastroDoxs has qualified gastroenterologists specializing in PSC. You can make a reservation for comprehensive examination, testing, and individualized care.

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