Primary Sclerosing Cholangitis (PSC) is a chronic liver disorder in which the bile ducts inside and outside the liver become inflamed, scarred, and narrowed. Over time, blocked bile flow can lead to progressive liver damage, cirrhosis, and complications such as bile duct infections or liver failure. PSC is often associated with inflammatory bowel disease, particularly ulcerative colitis, but it can also occur independently.
PSC may progress slowly, and early on you might not notice any signs. As the disease advances, watch for:
The exact cause of PSC is not fully understood, but several factors appear to play a role:
Our board-certified gastroenterologists specialize in managing Primary Sclerosing Cholangitis with advanced diagnostics, tailored treatment plans, and ongoing support. Don't wait to protect your liver-book your appointment today with our experienced PSC team at GastroDoxs in Cypress and take the first step toward better health.
We've successfully treated more than 1.5K patients, helping individuals improve their digestive health and overall well-being through expert, personalized care.
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Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
PSC is a progressive liver disease that can lead to cirrhosis, liver failure, or bile duct cancer if not managed. Early detection and ongoing care can slow progression and improve quality of life.
PSC is diagnosed through blood tests (liver enzymes, p-ANCA), imaging such as ultrasound and MRCP to visualize bile ducts, and sometimes ERCP to confirm strictures and obtain biopsies.
Yes. A nutrient-rich diet with lean proteins, whole grains, fruits, vegetables, healthy fats, and reduced sodium supports liver function and overall health. Vitamin supplementation may be needed if absorption is impaired.
While family history of liver or bile duct diseases raises risk, PSC is not strictly inherited. Immune system factors and other environmental triggers also play a role.
Perinuclear anti?neutrophil cytoplasmic antibodies (p-ANCA) are blood markers often elevated in PSC patients. They support the diagnosis but are not definitive on their own.
Ultrasound imaging can detect bile duct thickening, strictures, or dilation and assess liver texture, making it a noninvasive first step in PSC evaluation.
Researchers are studying novel medications, biological therapies, and endoscopic techniques to slow bile duct damage. Participation in clinical trials may be an option for eligible patients.
A transplant evaluation is recommended for patients with end-stage liver disease, recurrent bile duct infections, severe itching, or high risk of bile duct cancer that cannot be managed medically.
Routine follow-up every 3 to 6 months is typical to monitor symptoms, liver function tests, imaging studies, and adjust treatment as needed.
Yes. Although PSC is more common in adults aged 30-50, it can occur in pediatric patients. Early recognition and management are important to delay disease progression.
