Lymphocytic duodenitis is a condition where excess lymphocytes (a type of white blood cell) accumulate in the lining of the duodenum, the first part of the small intestine. This buildup leads to mild inflammation and irritation, which is most often diagnosed via biopsy during an upper endoscopy.
Symptoms can be subtle at first but may include:
Several factors can trigger lymphocyte overactivity in the duodenum:
At GastroDoxs in Houston, we specialize in diagnosing and treating lymphocytic duodenitis and other gastrointestinal conditions. Our patient-centered approach combines expert endoscopy services, personalized dietary guidance, and compassionate follow-up care to help you achieve lasting relief. Don't wait-book your appointment today and take the first step toward a healthier, more comfortable life.
We've successfully treated more than 306 patients, helping individuals improve their digestive health and overall well-being through expert, personalized care.
With over 20 years of experience, GastroDoxs has been a trusted provider of gastroenterology care, focusing on delivering the best outcomes for patients
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Lymphocytic duodenitis is an inflammatory condition in which too many lymphocytes (a type of white blood cell) collect in the lining of the duodenum, causing mild swelling and irritation.
It's most often diagnosed during an upper endoscopy when a small tissue sample (biopsy) from the duodenum shows an elevated count of lymphocytes under the microscope.
Yes. Early or mild celiac disease can present with similar duodenal lymphocytosis, but not everyone with lymphocytic duodenitis has full-blown celiac. Additional blood tests and response to a gluten-free diet help distinguish them.
Often, yes. Many patients improve on a gluten-free or other elimination diet tailored to their food sensitivities, which can reduce inflammation and alleviate symptoms.
Some people notice relief in a few weeks after starting dietary changes or medications, but complete healing of the duodenal lining can take longer and requires follow-up evaluation.
