Lymphocytic duodenitis is a mild inflammation of the duodenum-the first part of your small intestine-marked by an unusually high number of lymphocytes (immune cells) in the intestinal lining. It's most often discovered when a tissue sample is taken during an endoscopy. Although it can be tied to celiac disease, it may also occur with infections, certain medications or other immune-related conditions.
Early on, you might not notice any problems. As it progresses, common signs include:
Lymphocytic duodenitis can be triggered by a variety of factors, such as:
At GastroDoxs in Katy, our board-certified gastroenterologists combine cutting-edge endoscopy and biopsy techniques with a compassionate, patient-centered approach to diagnose and treat lymphocytic duodenitis. From customized dietary guidance and probiotic support to medication management and ongoing follow-up, we're committed to helping you achieve lasting relief and optimal digestive health. Call GastroDoxs today or book your appointment online-often with same-week availability!
We've successfully treated more than 1K patients, helping individuals improve their digestive health and overall well-being through expert, personalized care.
With over 20 years of experience, GastroDoxs has been a trusted provider of gastroenterology care, focusing on delivering the best outcomes for patients
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Lymphocytic duodenitis is inflammation of the duodenal lining marked by an increased number of lymphocytes (immune cells) seen on biopsy. It often causes digestive symptoms but is usually not life-threatening.
It's diagnosed via an upper endoscopy, during which a small tissue sample (biopsy) is taken from the duodenum and examined under a microscope for excess lymphocytes.
Yes. In people with celiac disease or gluten sensitivity, ingesting gluten can lead to lymphocytic duodenitis. A strict gluten-free diet is the primary treatment in these cases.
Besides gluten, causes include bacterial infections (e.g., H. pylori), certain medications (NSAIDs, antibiotics), autoimmune disorders, and food sensitivities.
Typical symptoms include abdominal pain, bloating, gas, diarrhea or loose stools, unexplained weight loss, and fatigue.
Treatment depends on the underlying cause. Options may include a gluten-free diet, probiotics, discontinuing offending medications, anti-inflammatory drugs for severe cases, and nutritional supplements for deficiencies.
With appropriate treatment-such as dietary changes or eradication of an infection-most patients see symptom improvement within 2-8 weeks.
Yes. Follow-up appointments may include repeat endoscopy or blood tests to monitor nutrient levels, verify healing, and adjust treatment as needed.
Yes. Children can also have this condition. Pediatric evaluation and management are important to ensure proper growth, nutrition, and symptom relief.
If you have persistent gut symptoms or have been diagnosed with lymphocytic duodenitis, schedule an appointment with the GastroDoxs gastroenterology team in Katy. We offer endoscopy, biopsy, and personalized care plans.
