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Lymphocytic Duodenitis
Discover expert diagnosis and treatment for lymphocytic duodenitis in Houston with Dr. Scott at GastroDoxs. Our personalized care plans, advanced endoscopy suite, and comprehensive diet and lifestyle guidance help you alleviate symptoms, address underlying causes, and restore optimal gut health.
Dr. Scott Liu, MD, is a board-certified gastroenterologist with over six years of experience and a background in military medicine. He earned his medical degree from the University of Maryland, Baltimore, completed his Internal Medicine residency at Naval Medical Center Portsmouth, and finished his Gastroenterology fellowship through the National Capital Consortium. Dr. Liu provides comprehensive care for a broad range of digestive conditions, including abdominal pain, acid reflux, liver disease, chronic diarrhea, and colon cancer screening. He is a member of the American College of Gastroenterology and is known for his disciplined, patient-focused approach and clear communication.
What Is Lymphocytic Duodenitis?
Lymphocytic duodenitis is an inflammatory condition of the duodenum (the first part of the small intestine) marked by an abnormal build-up of lymphocytes (white blood cells) in the intestinal lining. It can occur on its own or alongside celiac disease and may cause digestive symptoms detected on biopsy.
Common Causes and Risk Factors
Celiac disease (gluten sensitivity)
Helicobacter pylori infection
Frequent use of NSAIDs (e.g., ibuprofen)
Immune-related disorders such as Crohn's disease
Family history of digestive problems
Older age or chronic stress
Signs and Symptoms
Gas, bloating, or abdominal discomfort
Diarrhea or frequent loose stools
Unexplained weight loss
Fatigue or symptoms of nutrient deficiencies
How Dr. Scott Diagnoses This Condition?
Dr. Scott uses a step-by-step approach:
Medical History & Exam
He reviews your symptom pattern-especially epigastric pain-dietary triggers, medication use (NSAIDs, PPIs), alcohol intake, family history of GI disorders and other risk factors.
Blood Tests
We screen for celiac disease with tissue transglutaminase IgA (tTG-IgA) and total IgA levels, check a complete blood count (CBC) for anemia, and assess vitamin B12, folate and iron stores.
Upper Endoscopy & Biopsy
Directly visualizes the esophagus, stomach and duodenum to pinpoint inflammation or mucosal changes that could explain your epigastric pain.
Multiple duodenal biopsies are taken to count intraepithelial lymphocytes-over 25 per 100 enterocytes confirms lymphocytic duodenitis.
Additional Testing (if needed)
If H. pylori infection is suspected, we perform a breath or stool antigen test. In rare cases, we may order small-bowel imaging or a functional motility study to rule out strictures or other structural causes of pain.
Treatment
Our Team offers a full range of care for lymphocytic duodenitis.
1. Lifestyle and Diet Modifications
Remove gluten from your diet (if celiac disease is confirmed)
Take probiotics to support and balance gut flora
Follow a low-FODMAP plan to reduce gas and bloating
Incorporate light exercise and mindfulness to lower stress
2. Medications
Proton pump inhibitors (PPIs) or H2 blockers to reduce stomach acid and promote healing
Antibiotics to eradicate H. pylori infection, when present
Targeted supplements to correct vitamin and mineral deficiencies
3. Minimally Invasive or Advanced Procedures
Balloon dilation for areas of duodenal narrowing
Endoscopic treatments to address ulcers or mucosal irritation
Dr. Scott Liu, MD, is a board-certified gastroenterologist with over six years of experience and a background in military medicine. He earned his medical degree from the University of Maryland, Baltimore, completed his Internal Medicine residency at Naval Medical Center Portsmouth, and finished his Gastroenterology fellowship through the National Capital Consortium. Dr. Liu provides comprehensive care for a broad range of digestive conditions, including abdominal pain, acid reflux, liver disease, chronic diarrhea, and colon cancer screening. He is a member of the American College of Gastroenterology and is known for his disciplined, patient-focused approach and clear communication.
Frequently Asked Questions
What causes lymphocytic duodenitis?
Most cases are linked to celiac disease (gluten sensitivity), infections like H. pylori, or certain medications such as NSAIDs. Immune-related conditions and genetic factors can also contribute.
How long does it take to feel better?
With proper diet changes, medications, and lifestyle adjustments, many patients notice improvement within 4 to 8 weeks. Dr. Scott monitors your progress and tailors your plan as needed.
Is a biopsy really needed?
Yes. A biopsy of the duodenum during an upper endoscopy is the gold standard to confirm lymphocytic duodenitis and rule out other conditions.
Can this turn into celiac disease?
Sometimes. Lymphocytic duodenitis can be an early sign of celiac disease. Dr. Scott will follow you with blood tests and repeat evaluations to watch for progression.
Is it serious?
If left untreated, chronic inflammation can impair nutrient absorption and lead to deficiencies. Early diagnosis and management help prevent long-term complications.
Will diet changes help?
Yes. A gluten-free diet for those with celiac, plus a low-FODMAP or customized nutrition plan, often relieves symptoms and supports gut healing.
Does insurance cover this?
Most plans cover endoscopy, lab work, and nutrition consultations. Our team verifies your benefits and estimates out-of-pocket costs before your visit.
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