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Lymphocytic Duodenitis

Lymphocytic duodenitis, characterized by immune cell buildup in the duodenum, can cause bloating, mild pain and nutrient issues despite a normal-looking intestine. Dr. Rishi Chadha at GastroDoxs in Houston offers expert diagnosis, treatment and advanced endoscopy to restore digestive health.

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Rishi Chadha

About the Expert

Dr. Rishi Chadha, MD is a board‑certified gastroenterologist who specializes in preventive gastroenterology, colorectal cancer screening, and minimally invasive endoscopic procedures. He completed his fellowship at Sunrise Health GME in Las Vegas and previously trained in internal medicine at St. Vincent’s Medical Center in Connecticut.

What Is Lymphocytic Duodenitis?

Lymphocytic duodenitis is a mild inflammation of the duodenum (the first part of the small intestine) caused by an excess buildup of lymphocytes in the intestinal lining. Although the mucosa may look normal on endoscopic exam, biopsy reveals increased intraepithelial lymphocytes. When it leads to malabsorption, it's often coded as ICD-10 K90.41.

Common Causes and Risk Factors

  • Celiac disease (with or without full villous atrophy)
  • Other autoimmune disorders, such as type 1 diabetes or thyroid disease
  • Gastrointestinal infections
  • Medications like NSAIDs or proton pump inhibitors (PPIs)
  • Unknown triggers (many cases have no clear identifiable cause)

Signs and Symptoms

  • Bloating or excess gas
  • Mild abdominal pain or discomfort
  • Loose stools or mild diarrhea
  • Fatigue from impaired nutrient absorption
  • Symptoms often appear after meals or during periods of stress

How Dr. Rishi Chadha Diagnoses Lymphocytic Duodenitis?

Dr. Chadha uses a thorough, step-by-step approach:

1. Medical History

He asks about your symptoms, dietary habits, and any family history of gut problems.

2. Blood Tests

These check for celiac disease markers (eg, tissue transglutaminase antibodies) and assess key nutrient levels.

3. Endoscopy with Biopsy

A tiny camera examines the duodenal lining and Dr. Chadha takes a small tissue sample. The lab then counts lymphocytes-fewer than 25 per 100 cells is normal.

4. Follow-Up

He reviews your biopsy results in detail, explains what they mean, and answers all your questions to guide treatment.

Dr. Rishi Chadha
Treatment

Treatment Options at GastroDoxs in Houston

1. Diet and Lifestyle Tips

  • Try a gluten-light or gluten-free diet (even if you don-t have full celiac disease)
  • Eat cooked vegetables, lean meats, and low-fat dairy
  • Drink plenty of water each day

2. Medications

  • Acid blockers (PPIs or H2 blockers) to reduce stomach irritation
  • Budesonide (a gentle, local steroid) for tougher or persistent inflammation
  • Probiotics, as needed, to support healthy gut flora

3. Advanced Tools (if needed)

  • Minimally invasive endoscopic scopes to reassess healing
  • Repeat biopsy to confirm lymphocyte count reduction
  • Personalized follow-up plans-no surgery required in most cases
Rishi Chadha

About the Author

Dr. Rishi Chadha, MD is a board‑certified gastroenterologist who specializes in preventive gastroenterology, colorectal cancer screening, and minimally invasive endoscopic procedures. He completed his fellowship at Sunrise Health GME in Las Vegas and previously trained in internal medicine at St. Vincent’s Medical Center in Connecticut.

Frequently Asked Questions

What causes lymphocytic duodenitis?

Celiac disease (even without full villous damage), autoimmune disorders, gut infections, certain medications (NSAIDs or PPIs), or sometimes no clear trigger is found.

Is lymphocytic duodenitis serious?

It's generally mild but can lead to malabsorption and fatigue if untreated.

What is a normal lymphocyte count in the duodenum?

Under 25 lymphocytes per 100 epithelial cells is considered normal.

Is lymphocytic duodenitis linked to celiac disease?

Yes. Many patients show early celiac changes without complete villous atrophy.

What is the ICD-10 code for this condition?

ICD-10 code K90.41 is used when lymphocytic duodenitis is associated with malabsorption.

Can diet help manage lymphocytic duodenitis?

Yes. Adopting a gluten-free or gluten-light diet, eating lean proteins and cooked vegetables, and staying hydrated often improves symptoms.

Do I need an endoscopy to diagnose it?

Yes. A duodenal biopsy during endoscopy is required to count lymphocytes and confirm the diagnosis.

How soon will I feel better after starting treatment?

Most patients notice improvement within 4 to 8 weeks of dietary changes and/or medication.

Will I need surgery?

No. Treatment relies on diet, lifestyle adjustments, and medications'surgery is not needed.

How do I schedule an appointment with Dr. Chadha?

Call the GastroDoxs office in Houston. Our team will help with insurance, prep instructions, and appointment times.

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