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Abnormal Liver Function Studies (Lfts)

At GastroDoxs in Houston, Dr. Nghia Nguyen offers expert comprehensive care for abnormal liver function tests (LFTs). Utilizing advanced diagnostics and personalized treatment, he evaluates causes—from hepatitis to fatty liver—guiding patients toward improved liver health, symptom relief, and lasting well-being.

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Nghia Nguyen

About the Expert

Dr. Nghia Nguyen, DO, is a board-certified gastroenterologist providing advanced digestive care in the Greater Houston area. He earned his medical degree from the Texas College of Osteopathic Medicine and completed both his Internal Medicine residency and Gastroenterology fellowship at the University of Texas at Rio Grande Valley. Dr. Nguyen specializes in treating conditions such as acid reflux, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and liver disorders.

What Are Abnormal Liver Function Studies (LFTs)?

Liver function tests measure key enzymes and proteins in your blood—such as ALT, AST, ALP and bilirubin—to assess how well your liver is working. When one or more values fall outside the normal range, it may signal liver injury, inflammation or impaired bile flow that requires further evaluation.

Common Causes and Risk Factors

  • Viral hepatitis (A, B or C)
  • Nonalcoholic fatty liver disease (obesity, insulin resistance)
  • Excessive alcohol consumption
  • Medications or toxins (e.g., acetaminophen, herbal supplements)
  • Autoimmune hepatitis
  • Inherited disorders (hemochromatosis, Wilson's disease)
  • Cholestatic diseases (primary biliary cholangitis, primary sclerosing cholangitis)
  • Biliary obstruction (gallstones, tumors)
  • Acute fatty liver of pregnancy

Signs and Symptoms

  • Often none in early stages
  • Fatigue, weakness or low energy
  • Loss of appetite or unexplained weight loss
  • Upper abdominal discomfort or fullness
  • Jaundice (yellowing of skin and eyes)
  • Dark urine or pale stools
  • Itchy skin
  • Swelling in legs (edema) or abdomen (ascites) in advanced disease

How Dr. Nghia Nguyen Diagnoses Abnormal Liver Function Studies (LFTs)?

Dr. Nguyen uses a step-by-step approach:

Medical History and Physical Exam

He reviews your symptoms—especially epigastric pain—along with alcohol use, medication history, family liver disease, and risk factors for viral hepatitis.

Blood Tests

We order a comprehensive panel:

  • Liver enzymes (ALT, AST, ALP, GGT) and bilirubin levels
  • Viral hepatitis markers (A, B, C)
  • Pancreatic enzymes (amylase, lipase) if epigastric pain suggests pancreas involvement
  • Autoimmune or metabolic panels to rule out rarer causes

Imaging Studies

  • Abdominal ultrasound to assess liver texture, gallbladder, and biliary tree
  • FibroScan (elastography) to measure liver stiffness
  • CT or MRI if structural lesions, masses, or complications are suspected

Endoscopic Evaluation (if indicated)

Upper endoscopy may be performed to identify peptic ulcers, gastritis, or varices that can contribute to epigastric pain.

Advanced Testing (as needed)

If noninvasive studies are inconclusive, a liver biopsy can confirm inflammation, fibrosis, or specific histologic diagnoses.

Nghia Nguyen
Treatment

Treatment Options at GastroDoxs in Houston

1. Lifestyle and Diet Changes

  • A diet rich in vegetables, fruits, and lean proteins
  • Cutting down on sugary drinks and processed foods
  • Avoiding alcohol
  • Gradual weight loss if you have fatty liver

2. Medications

  • Antiviral drugs for hepatitis
  • Immune-suppressing medicine for autoimmune liver disease
  • Cholesterol-lowering medicine for fatty liver

3. Advanced Treatment Options

  • Endoscopic treatment for bleeding from liver-related veins
  • TIPS procedure to lower pressure in liver blood vessels
  • Referral to a transplant team if needed
Dr Nghia Nguyen

About the Author

Dr. Nghia Nguyen, DO, is a board-certified gastroenterologist providing advanced digestive care in the Greater Houston area. He earned his medical degree from the Texas College of Osteopathic Medicine and completed both his Internal Medicine residency and Gastroenterology fellowship at the University of Texas at Rio Grande Valley. Dr. Nguyen specializes in treating conditions such as acid reflux, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and liver disorders.

Frequently Asked Questions

What causes a fatty liver?

Fat often collects in the liver from poor diet, obesity, diabetes, alcohol use, or certain medications.

How can I lower my liver enzymes?

Eat a balanced diet, exercise regularly, and avoid excess alcohol. Dr. Nguyen creates a personalized plan to help you lower liver enzyme levels.

What tests show hepatic echogenicity?

A fatty liver ultrasound or FibroScan measures echogenic liver changes without surgery.

Is there a drug for fatty liver disease?

Yes. We use FDA-approved medications for fatty liver disease when lifestyle changes alone aren't enough.

What is NASH liver disease life expectancy?

It varies by stage. Early NASH can often be managed with diet and exercise. Dr. Nguyen will discuss your individual prognosis.

Do I need a biopsy?

Most patients avoid biopsy. We rely on blood tests, imaging, and non-invasive scans unless advanced disease is suspected.

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