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Pancreatic Insufficiency

Pancreatic insufficiency, or exocrine pancreatic insufficiency (EPI), occurs when the pancreas cannot produce sufficient digestive enzymes, hindering nutrient absorption. At GastroDoxs in Houston, Dr. Bharat Pothuri offers expert diagnosis, personalized treatment plans, and compassionate care to restore optimal digestive health.

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Texas Medical Board
Harris County Medical Society
American College of Gastroenterology
American Society for Gastrointestinal Endoscopy
Memorial hermann
Houston Methodist leading Medicine
HCA Houston Healthcare
Bharat Pothuri

About the Expert

Dr. Bharat Pothuri is a board-certified gastroenterologist and the founder of GastroDoxs. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.

Common Causes and Risk Factors

  • Chronic pancreatitis (long-term inflammation of the pancreas)
  • Cystic fibrosis and other inherited disorders
  • Surgery, trauma, or injury to the pancreas
  • Advanced diabetes leading to pancreatic damage
  • Age-related decline in digestive enzyme production
  • Heavy alcohol consumption
  • Tobacco use
  • Family history of pancreatic disease

Signs and Symptoms

  • Oily, greasy, or foul-smelling stools (steatorrhea)
  • Unexplained weight loss despite normal appetite
  • Excessive gas, bloating, or abdominal discomfort
  • Deficiencies of fat-soluble vitamins (A, D, E, K)
  • Persistent fatigue or weakness

Expert Treatment for Pancreatic Insufficiency by Dr. Bharat Pothuri

Dr. Pothuri uses a step-by-step approach:

Medical History and Physical Exam

He reviews your abdominal pain pattern (timing, triggers, radiation), weight changes, stool characteristics (steatorrhea), and risk factors such as alcohol use, smoking, diabetes, or family history of pancreatic disease.

Blood Tests

He orders serum amylase and lipase to detect pancreatic inflammation, liver function tests to rule out hepatobiliary causes, glucose/HbA1c to assess endocrine function, and fat-soluble vitamin levels (A, D, E, K) to check for malabsorption.

Stool Tests

Fecal elastase measurement evaluates exocrine pancreatic output, while quantitative stool fat testing confirms steatorrhea.

Imaging Studies

  • Abdominal ultrasound screens for pancreatic calcifications, ductal dilation, or gallstones.
  • CT scan or MRI/MRCP provides detailed views of gland morphology, ductal anatomy, inflammation, or masses.

Specialized Function Testing (if needed)

Secretin stimulation testing or endoscopic ultrasound (EUS) may be used to directly assess enzyme secretion and tissue integrity, and to guide therapeutic interventions like ERCP if blockages or stones are identified.

Bharat Pothuri
Treatment

Our Team offers a full range of care for exocrine pancreatic insufficiency.

1. Lifestyle and Diet Modifications

  • Eat small, frequent meals to ease digestion
  • Avoid alcohol and quit smoking to protect pancreatic function
  • Choose low-fat, high-protein foods for optimal nutrition
  • Take prescribed enzyme pills with every meal and snack

2. Medications

  • Pancreatic enzyme replacement therapy to improve nutrient absorption
  • Targeted vitamin supplements (A, D, E, K) to correct deficiencies
  • Additional agents as needed for pain or digestive support

3. Minimally Invasive or Advanced Procedures

  • ERCP with stone removal or ductal stent placement to relieve blockages
  • Endoscopic interventions for strictures or chronic pancreatitis changes
  • Advanced imaging-guided therapies when indicated
1.5K

Patients Treated

Dr. Pothuri has treated more than 1.5K patients, helping individuals improve their digestive health and overall well-being through expert, personalized care.

20Y

Years of Experience

With over 20 years of experience, GastroDoxs has been a trusted provider of gastroenterology care, focusing on delivering the best outcomes for patients

Bharat Pothuri

About the Author

Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.

Frequently Asked Questions

What tests confirm pancreatic insufficiency?

Diagnosis is confirmed through stool elastase, blood vitamin levels, and imaging tests like ultrasound, CT, or MRI.

How soon will I feel better with enzyme pills?

Most patients notice symptom relief within 1-2 weeks of starting enzyme replacement therapy.

Can I manage this with diet alone?

Diet modifications help, but enzyme replacement therapy is usually necessary to ensure proper nutrient absorption.

Are there side effects with enzyme pills?

Most people tolerate enzyme supplements well; rare side effects include mild abdominal cramps or constipation.

Does insurance cover treatment?

Most insurance plans cover enzyme therapy and related tests. Our billing team can verify your benefits.

Can children get pancreatic insufficiency?

Yes. Conditions like cystic fibrosis can cause exocrine pancreatic insufficiency in children. Early diagnosis is key.

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