What Is Lymphocytic Duodenitis?
Lymphocytic duodenitis is inflammation of the duodenum (the first part of the small intestine) caused by an excessive buildup of lymphocytes (a type of white blood cell) in its lining. It often leads to abdominal discomfort, bloating, and digestive issues after meals.
Common Causes and Risk Factors
- Celiac disease or other autoimmune disorders
- Food sensitivities (gluten, dairy, etc.)
- Bacterial or viral gastrointestinal infections
- Use of NSAIDs and certain other medications
- Family history of gut-related conditions
Signs and Symptoms
- Abdominal pain or cramps, especially after eating
- Bloating and excessive gas
- Nausea or occasional mild vomiting
- Unintended weight loss
- Fatigue, weakness, or iron-deficiency anemia
Expert Treatment for Lymphocytic Duodenitis by Dr. Bharat Pothuri
Dr. Pothuri uses a step-by-step approach:
Medical History and Physical Exam
He discusses your epigastric pain, eating habits, family history of gut disorders, and other risk factors.
Blood Tests
We screen for celiac disease antibodies, check nutrient levels (iron, B12), and rule out other immune-mediated causes.
Endoscopic Evaluation
An upper endoscopy allows direct visualization of the duodenum and collection of small biopsies to quantify lymphocyte infiltration.
Breath Tests
- Hydrogen breath test to assess for small intestinal bacterial overgrowth (SIBO).
- Lactose or fructose breath tests to identify carbohydrate malabsorption.
Frequently Asked Questions
What is lymphocytic duodenitis?
It's inflammation of the duodenum marked by excess lymphocytes in the lining, causing pain, bloating, and malabsorption.
How is it diagnosed?
Diagnosis uses endoscopy with biopsy showing increased intraepithelial lymphocytes, plus blood tests to exclude celiac disease.
What causes lymphocytic duodenitis?
Causes include celiac spectrum, NSAIDs, food sensitivities, infections, and autoimmune conditions.
How is it treated?
Treatment involves dietary changes (gluten?free or low?FODMAP), acid suppression, and nutritional supplementation.