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Collagenous Colitis

Collagenous colitis is a chronic inflammatory condition of the colon causing persistent watery diarrhea and discomfort. At GastroDoxs, Houston-based Dr. Bharat Pothuri combines dietary guidance, targeted medications and endoscopic therapies to deliver personalized care and lasting relief for microscopic colitis. External Resource For more on microscopic colitis, see the National Institute of Diabetes and Digestive and Kidney Diseases: https://www.niddk.nih.gov/health-information/digestive-diseases/microscopic-colitis

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Bharat Pothuri

About the Expert

Dr. Bharat Pothuri is a board-certified gastroenterologist and the founder of GastroDoxs. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.

What Is Collagenous Colitis?

Collagenous colitis is a type of microscopic colitis that leads to chronic, watery diarrhea. Under a microscope, a pathologist sees a thickened band of collagen (a structural protein) just beneath the lining of the colon. Despite normal appearance on standard colonoscopy, tissue biopsies confirm the diagnosis.

Common Causes and Risk Factors

  • Age over 50
  • Use of certain medications (NSAIDs, some antidepressants like SSRIs)
  • Existing autoimmune diseases (such as thyroid disorders or celiac disease)
  • History of smoking
  • Female gender (slightly higher incidence)

Signs and Symptoms

  • Persistent, watery diarrhea (often several times per day)
  • Sudden urgency to use the bathroom
  • Abdominal cramping or discomfort
  • Mild unintended weight loss
  • Fatigue or weakness from fluid loss

Expert Treatment for Collagenous Colitis by Dr. Bharat Pothuri

Dr. Pothuri uses a step-by-step approach:

Medical History and Physical Exam

He reviews your diarrhea pattern (including urgency and frequency), any abdominal or epigastric discomfort, medication use (NSAIDs, SSRIs), smoking history, and coexisting autoimmune conditions.

Laboratory and Stool Studies

We draw blood to check for anemia or inflammation (CBC, CRP) and obtain stool samples to rule out infections, parasites, and other inflammatory bowel diseases.

Colonoscopy with Biopsy

  • Direct visualization of the colon lining to assess for subtle mucosal changes.
  • Multiple tissue samples are taken pathology looks for the hallmark thickened subepithelial collagen band.

Additional Evaluation (if needed)

In rare or atypical cases, Dr. Pothuri may order cross-sectional imaging (CT or MRI enterography) or capsule endoscopy to exclude small-bowel pathology as a cause of chronic diarrhea or upper-abdominal discomfort.

Bharat Pothuri
Treatment

Our Team offers a full range of care for collagenous colitis.

1. Lifestyle and Diet Modifications

  • Limit caffeine and carbonated drinks
  • Avoid high-fat or fried foods
  • Steer clear of sugar substitutes such as sorbitol and mannitol
  • Reduce or eliminate dairy if you're lactose intolerant
  • Personalized meal plans tailored to the Houston climate and local cuisine

2. Medications

  • Anti-diarrheal agents (loperamide) to control stool frequency
  • Budesonide-a targeted steroid to reduce colon inflammation
  • Bile acid binders (cholestyramine) to manage bile-related diarrhea

3. Minimally Invasive or Advanced Procedures

  • Endoscopic therapy for localized treatment of severe cases
  • Minimally invasive colon procedures to address persistent symptoms
  • Access to clinical trials and novel microscopic colitis interventions
1.5K

Patients Treated

Dr. Pothuri has treated more than 1.5K patients, helping individuals improve their digestive health and overall well-being through expert, personalized care.

20Y

Years of Experience

With over 20 years of experience, GastroDoxs has been a trusted provider of gastroenterology care, focusing on delivering the best outcomes for patients

Bharat Pothuri

About the Author

Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.

Frequently Asked Questions

What is collagenous colitis?

Collagenous colitis is a form of microscopic colitis that causes chronic, watery diarrhea and shows a thickened collagen band under the colon lining when viewed under a microscope.

What causes collagenous colitis?

The exact cause is unknown, but risk factors include age over 50, certain medications (NSAIDs, some antidepressants), autoimmune conditions, smoking history, and female gender.

What should I avoid eating with collagenous colitis?

Avoid or limit caffeine, carbonated drinks, high-fat or fried foods, sugar substitutes (sorbitol, mannitol), and dairy if you're lactose intolerant.

How is collagenous colitis diagnosed?

Diagnosis requires a colonoscopy with biopsy. A pathologist examines tissue samples for the characteristic thick collagen layer beneath the colon lining.

What treatments are available for collagenous colitis?

Treatment may include dietary modifications, anti-diarrheal agents (like loperamide), budesonide (a targeted steroid), and bile acid binders (cholestyramine). Severe cases might require endoscopic therapy.

Can diet alone cure collagenous colitis?

Dietary changes help many patients, but some also need medication or minimally invasive procedures to control symptoms effectively.

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