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Primary Biliary Cirrhosis in Texas

Dr. Bharat Pothuri Medically Reviewed by Dr. Bharat Pothuri, MD, FACG  |  Updated 03-17-2026

Our accomplished hepatology team at the GastroDoxs of Houston offers personalized care and treatment of cases of primary biliary cirrhosis and offers the best advanced care, supportive and community-focused liver health services to enable the locals cope with the symptoms and retard the disease progression and enhance the general liver health of the patient.

Dr. Bharat Pothuri, MD, FACG

Dr. Bharat Pothuri

MD, FACG

4.7  ·  1,900+ Reviews

Condition Overview

Our accomplished hepatology team at the GastroDoxs of Houston offers personalized care and treatment of cases of primary biliary cirrhosis and offers the best advanced care, supportive and community-focused liver health services to enable the locals cope with the symptoms and retard the disease progression and enhance the general liver health of the patient.

Symptoms

What is Primary Biliary Cirrhosis?

Primary Biliary Cirrhosis (PBC) is a chronic autoimmune liver disease in which the body’s immune system gradually damages the small bile ducts inside the liver. When these ducts are injured, bile begins to build up, causing inflammation and scarring (cirrhosis). Early detection and treatment can help slow disease progression and maintain healthy liver function.

Common Symptoms

In the early stages, PBC may not show any symptoms. As the condition progresses, you may experience:

  • Persistent fatigue or exhaustion
  • Itchy skin (pruritus)
  • Dry eyes and/or dry mouth
  • Discomfort or pain in the upper right side of the abdomen
  • Jaundice (yellowing of the skin and eyes)
  • Dark urine and pale, clay-colored stools

Causes

The exact cause of PBC is still unclear, but several factors are believed to contribute:

  • An autoimmune reaction that targets the small bile ducts
  • Genetic predisposition or family history of liver disease
  • Environmental triggers such as certain chemicals or infections
  • Gender-PBC occurs more commonly in women

Treatment Options

Treatment Options for Primary Biliary Cirrhosis in Houston

Treatment includes medication, monitoring, and lifestyle support:

  • Ursodeoxycholic acid (UDCA): Improves bile flow and protects liver cells.
  • Obeticholic acid: Alternative therapy for patients who don't respond adequately to UDCA.
  • Symptom-relief medications: Treatments to reduce itching and supplements to maintain bone strength.
  • Regular checkups: Ongoing blood tests, liver imaging, and sometimes a liver biopsy to monitor disease progression.
  • Lifestyle support: Tailored diet advice, an exercise plan, and guidance on avoiding alcohol to support overall liver health.

What Else Should You Know?

Ready to Take Control of Your Liver Health?

At GastroDoxs, our Houston team specializes in Primary Biliary Cirrhosis (PBC) care, offering board-certified expertise, on-site testing, and individualized treatment plans. From ursodeoxycholic acid to symptom relief and lifestyle guidance, we're dedicated to slowing disease progression and improving your quality of life. Don't wait-book your appointment today and partner with us for compassionate, patient-centered PBC care.

GastroDoxs Experience

Patients Treated

We've successfully treated more than 1.5K patients, helping individuals improve their digestive health and overall well-being through expert, personalized care.

Years of Experience

With over 20 years of experience, GastroDoxs has been a trusted provider of gastroenterology care, focusing on delivering the best outcomes for patients

About the Author

Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.

Frequently Asked Questions

What is Primary Biliary Cirrhosis (PBC)?

Primary Biliary Cirrhosis is a chronic autoimmune liver disease in which the body's immune system attacks the small bile ducts, leading to bile buildup, inflammation, and gradual scarring (cirrhosis) of the liver.

What are the common symptoms of Primary Biliary Cirrhosis?

Early on, you may have no symptoms. As PBC progresses, common signs include fatigue, itchy skin, dry eyes or mouth, upper right abdominal discomfort, jaundice (yellowing of the skin or eyes), dark urine, and pale stools.

How is Primary Biliary Cirrhosis (PBC) diagnosed?

PBC is diagnosed through a combination of blood tests (including anti-mitochondrial antibodies or AMA), imaging studies such as ultrasound, and sometimes a liver biopsy to assess the extent of duct damage and scarring.

How is PBC different from Primary Sclerosing Cholangitis (PSC)?

While both are chronic cholestatic liver diseases, PBC primarily affects small intrahepatic bile ducts in women and involves an autoimmune process. PSC affects larger bile ducts, is more common in men, and often coexists with inflammatory bowel disease.

What is the ICD-10 code for Primary Biliary Cirrhosis?

The ICD-10 code for Primary Biliary Cirrhosis is K74.3, which is used for medical records, billing, and insurance purposes.

Is there a treatment for Primary Biliary Cirrhosis?

There is no cure for PBC, but treatments like ursodeoxycholic acid (UDCA), obeticholic acid, symptom-relief medications, and lifestyle modifications can slow disease progression and improve quality of life.

Can a gastroenterologist treat Primary Biliary Cirrhosis?

Yes. Gastroenterologists are trained to manage liver diseases, including PBC, offering diagnostics, medication management, regular monitoring, and patient education.

Is Primary Biliary Cirrhosis curable?

No, PBC is not curable. However, early diagnosis and adherence to treatment and lifestyle recommendations can effectively manage symptoms and slow liver damage.

When should I see a doctor for possible PBC?

You should consult a healthcare provider if you experience persistent fatigue, unexplained itching, dry eyes or mouth, upper right abdominal discomfort, or if routine liver tests return abnormal results.

Where can I find a PBC specialist in Houston?

For expert PBC care in Houston, visit GastroDoxs. Our board-certified gastroenterologists provide personalized treatment plans, on-site testing, and compassionate support for patients and families.