| Brand Name | Aloxi |
| Generic Name | Palonosetron |
| Drug Class | Antiemetic |
| Availability | Prescription |
| Manufacturer | Helsinn Therapeutics |
| Indications | Prevention of chemotherapy-induced nausea |
| Type | Injection |
| Doses | 0.25 mg IV |
| Route | Intravenous |
| Side Effects | Headache, constipation |
| Interactions | SSRIs, antipsychotics |
| Overdose | Contact poison control and seek help |
| Missed Dose | Administer as soon as possible |
| Contraindications | Hypersensitivity to palonosetron |
| Alternatives | Ondansetron, Granisetron |
| Co-Pay Assistance Program | Available |
| Patient Assistance Program | Available |
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Nausea and vomiting that are due to chemotherapy or radiations are prevented by palonosetron.
Palonosetron acts by inhibiting serotonin receptors in the brain and in the gastrointestinal tract which are responsible in causing an effect of a nausea and vomiting caused by chemotherapy.
The side effects are commonly constipation, headache and fatigue. Serious side effects can be experienced such as chest pain or irregular heartbeats.
Palonosetron is the drug that is usually given by the healthcare provider as an intravenous (IV) infusion, usually just before chemotherapy.
Palonosetron can only be applied when absolutely necessary and this is in case of pregnancy. Your medical practitioner should be consulted in the case of being pregnant or conceiving a pregnancy.
Palonosetron is not an effective treatment of motion sickness but rather chemotherapy induced nausea and vomiting. Talk to your medical professional of motion sickness.
In case of omitting a dose, take it immediately and before chemotherapy session. In the event that it has been missed but it is near the next time of a regular dose, leave the missed dose behind and resume the dosage.
Yes, one of the common side effects of Palonosetron is headaches. In case the headaches are intense or maintaining then consult your healthcare provider.
Palonosetron can be combined with other drugs that alter the amount of serotonin. Ensure you always tell your health practitioner concerning all the medications you are taking.
Palonosetron is effective in the prevention of nausea and vomiting associated with chemotherapy and radiations with a considerable number of patients reporting a substantial reduction.
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