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Primary Biliary Cirrhosis

Dr. Rishi Chadha at GastroDoxs in Houston offers expert diagnosis and treatment for primary biliary cirrhosis (primary biliary cholangitis). Using advanced imaging, blood tests, personalized medications, and lifestyle guidance, he provides comprehensive liver care to manage symptoms and slow progression.

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Rishi Chadha

About the Expert

Dr. Rishi Chadha, MD is a board‑certified gastroenterologist who specializes in preventive gastroenterology, colorectal cancer screening, and minimally invasive endoscopic procedures. He completed his fellowship at Sunrise Health GME in Las Vegas and previously trained in internal medicine at St. Vincent’s Medical Center in Connecticut.

What Is Primary Biliary Cirrhosis?

Primary biliary cirrhosis (also called primary biliary cholangitis) is a chronic liver condition in which the immune system progressively destroys the small bile ducts inside the liver. Bile buildup damages liver cells over time, leading to scarring (cirrhosis). The ICD-10 code for this disease is K74.3.

Common Causes and Risk Factors

  • Autoimmune attack on the bile ducts
  • Predominantly affects women aged 30-60
  • Family history of autoimmune liver disease
  • Coexisting autoimmune disorders (thyroid disease, Sj-gren's syndrome, rheumatoid arthritis)
  • Genetic predisposition (certain risk genes identified)

Signs and Symptoms

  • Often none in early stages
  • Persistent fatigue
  • Itchy skin (pruritus)
  • Jaundice (yellowing of skin or eyes)
  • Dry eyes and mouth
  • Upper right-side abdominal discomfort
  • Dark urine and/or pale stools

How Dr. Rishi Chadha Diagnoses Primary Biliary Cirrhosis?

At GastroDoxs in Houston, Dr. Chadha uses a step-by-step approach:

Medical History and Exam

He reviews your symptoms, personal and family history of liver or autoimmune disease, and performs a physical exam to look for signs like jaundice or liver enlargement.

Blood Tests

He checks liver enzyme levels, bilirubin, and anti-mitochondrial antibodies (AMA) to detect autoimmune activity targeting the bile ducts.

Imaging Tests

  • Ultrasound - Evaluates liver texture and rules out gallstones or masses.
  • MRCP (Magnetic Resonance Cholangiopancreatography) - Provides detailed images of the bile ducts.

Elastography

This non-invasive scan measures liver stiffness, helping gauge the extent of fibrosis or early cirrhosis.

Liver Biopsy

In selected cases, a small tissue sample confirms the diagnosis, stages the disease, and rules out other liver conditions.

Dr. Rishi Chadha
Treatment

Expert Treatment Options for Primary Biliary Cirrhosis

1. Lifestyle and Diet Changes

  • Adopt a healthy, low-fat diet rich in fruits and vegetables
  • Avoid alcohol and reduce sodium intake
  • Engage in gentle, regular exercise to maintain fitness
  • Steer clear of over-the-counter medications that can harm your liver

2. Medications

  • Ursodeoxycholic acid (UDCA) to improve bile flow and slow disease progression
  • Obeticholic acid when UDCA alone is insufficient
  • Antihistamines or bile acid binders for itch relief
  • Vitamin D and calcium supplements to support bone health

3. Advanced Procedures (If Needed)

  • ERCP to relieve or correct bile duct blockages
  • Liver transplant evaluation for advanced cirrhosis or treatment-resistant disease
  • Access to clinical trials offering novel therapies
Rishi Chadha

About the Author

Dr. Rishi Chadha, MD is a board‑certified gastroenterologist who specializes in preventive gastroenterology, colorectal cancer screening, and minimally invasive endoscopic procedures. He completed his fellowship at Sunrise Health GME in Las Vegas and previously trained in internal medicine at St. Vincent’s Medical Center in Connecticut.

Frequently Asked Questions

What are early signs of primary biliary cirrhosis?

Tiredness, mild itching, and dry eyes. Some people have no symptoms early on.

How is it diagnosed?

Blood tests, imaging (ultrasound or MRCP), liver stiffness test, and sometimes a biopsy.

Can diet reverse the damage?

No. A good diet supports the liver but doesn-t reverse scarring.

What does UDCA do?

It improves bile flow and slows disease progress.

Are there newer treatments?

Yes. Obeticholic acid and newer drugs in clinical trials are showing good results.

When should I see a liver doctor?

If you have abnormal liver tests, itching, or fatigue that won-t go away.

Is it genetic?

Genes play a part, but it's not inherited directly like some diseases.

What does ICD-10 code K74.3 mean?

It is the code doctors and insurance use to label this liver disease.

Can I live a normal life with PBC?

Yes. Many people manage symptoms and live well with proper care.

When is transplant needed?

In late stages, if medications stop working or complications arise.

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