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Primary Sclerosing Cholangitis

Primary sclerosing cholangitis (PSC) is a chronic liver disease marked by bile duct inflammation and scarring, often linked to ulcerative colitis. In Houston, Dr. Bharat Pothuri at GastroDoxs offers comprehensive PSC care-from diagnosis through personalized treatments and advanced innovative interventions.

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Bharat Pothuri

About the Expert

Dr. Bharat Pothuri is a board-certified gastroenterologist and the founder of GastroDoxs. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.

Common Causes and Risk Factors

  • Inflammatory bowel disease, especially ulcerative colitis
  • Genetic and autoimmune predisposition
  • Male gender, typically between ages 30 and 50
  • Family history of PSC or other autoimmune disorders
  • Potential environmental triggers or infections

Signs and Symptoms

  • Often no symptoms in early stages
  • Fatigue or general weakness
  • Itchy skin (pruritus)
  • Jaundice (yellowing of the skin and eyes)
  • Discomfort or pain in the upper right abdomen
  • Dark urine and pale, clay-colored stools
  • Unexplained weight loss

Expert Treatment for Primary Sclerosing Cholangitis by Dr. Bharat Pothuri

Dr. Pothuri uses a step-by-step approach:

Medical History and Physical Exam

He reviews your symptoms-especially epigastric pain, itching, fatigue, and any changes in stool or urine color-and looks for risk factors such as ulcerative colitis or a family history of autoimmune disease.

Blood Tests

We check liver function tests (alkaline phosphatase, GGT, bilirubin) and autoimmune markers (p-ANCA) to identify cholestasis and rule out other liver disorders.

Imaging Studies

  • MRCP (Magnetic Resonance Cholangiopancreatography) to noninvasively visualize bile duct strictures and areas of inflammation.
  • Abdominal ultrasound to assess ductal dilation and liver texture changes.

Advanced Testing (if needed)

ERCP (Endoscopic Retrograde Cholangiopancreatography) allows direct inspection, sampling, and stent placement in narrowed ducts. A liver biopsy may be performed rarely to confirm diagnosis and stage fibrosis.

Bharat Pothuri
Treatment

Our Team offers a full range of care for primary sclerosing cholangitis.

1. Diet and Lifestyle Modifications

  • Balanced, low-fat and high-fiber meal plans
  • Calcium and vitamin D supplementation to protect bone health
  • Guidance on alcohol avoidance and gentle exercise (walking, yoga)

2. Medications

  • Ursodeoxycholic acid to improve bile flow
  • Cholestyramine or rifampin for relief of itching
  • Vitamins A, D, E and K supplements for malabsorption
  • Immune-modulating therapies in select cases

3. Minimally Invasive or Advanced Procedures

  • Endoscopic dilation and stenting of narrowed bile ducts
  • Ongoing monitoring and management of advanced scarring
  • Coordination with liver transplant teams for transplant evaluation
1.5K

Patients Treated

Dr. Pothuri has treated more than 1.5K patients, helping individuals improve their digestive health and overall well-being through expert, personalized care.

20Y

Years of Experience

With over 20 years of experience, GastroDoxs has been a trusted provider of gastroenterology care, focusing on delivering the best outcomes for patients

Bharat Pothuri

About the Author

Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.

Frequently Asked Questions

What is the difference between PBC and PSC?

PSC usually affects the larger bile ducts and is more common in people with ulcerative colitis. PBC mainly targets smaller bile ducts and occurs more often in women.

How are antibody tests used in PSC?

Blood tests check for immune markers that support a PSC diagnosis. Results are interpreted alongside imaging studies like MRCP or ERCP.

Is PSC treatment available in Houston?

Yes. GastroDoxs in Houston offers comprehensive PSC care, including diagnostic testing, medical management, endoscopic procedures, and transplant coordination.

Can PSC lead to cirrhosis?

Yes. Chronic bile duct inflammation and scarring can progress to cirrhosis if untreated. Early intervention helps slow or prevent liver damage.

Do I need a special diet for PSC?

A balanced diet low in saturated fat and rich in fiber and vitamins is recommended. Dr. Pothuri's team provides tailored nutritional guidance and supplements as needed.

When is liver transplant needed?

A transplant is considered if liver function deteriorates significantly or symptoms become severe despite optimal medical and endoscopic therapy. Dr. Pothuri collaborates with Houston transplant centers.

How often should I follow up with my doctor?

Follow-up visits are generally scheduled every 3 to 6 months, based on your blood tests, imaging results, and how you're feeling clinically.

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