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Indeterminate Colitis

Indeterminate colitis combines elements of Crohn's disease and ulcerative colitis, complicating diagnosis. At GastroDoxs in Houston, board-certified gastroenterologist Dr. Bharat Pothuri provides thorough evaluation-from advanced testing to tailored treatments-focused on reducing symptoms, restoring gut comfort, and enhancing quality of life.

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Bharat Pothuri

About the Expert

Dr. Bharat Pothuri is a board-certified gastroenterologist and the founder of GastroDoxs. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.

What Is Indeterminate Colitis?

Indeterminate colitis is a form of inflammatory bowel disease that has overlapping features of both ulcerative colitis and Crohn's disease. It is diagnosed when symptoms, endoscopic findings, and tissue biopsies do not clearly match one condition. Patients experience chronic inflammation in the colon, and a careful review of symptoms, medical history, and diagnostic tests is needed to guide treatment.

Common Causes and Risk Factors

  • Family history of inflammatory bowel disease (IBD)
  • Immune system dysfunction attacking the intestinal lining
  • Environmental triggers such as infections or psychological stress
  • Cigarette smoking
  • Typical age of onset between 15 and 35 years

Signs and Symptoms

  • Abdominal pain and cramping
  • Frequent, urgent bowel movements
  • Diarrhea, sometimes with blood
  • Fatigue and unintentional weight loss
  • Low-grade fever during active inflammation

Expert Treatment for Indeterminate Colitis by Dr. Bharat Pothuri

Dr. Pothuri uses a comprehensive, step-by-step approach:

Medical History and Symptom Review

He evaluates your epigastric pain, bowel habits, weight changes, family history of IBD, and other risk factors.

Laboratory Tests

Blood work checks for inflammation markers (CRP, ESR), anemia, electrolyte imbalances, and nutritional deficiencies.

Stool Studies

  • Stool cultures to rule out infection
  • Fecal calprotectin to quantify gut inflammation

Endoscopic Evaluation

  • Colonoscopy with targeted biopsies to examine the colon lining and obtain tissue samples
  • Upper endoscopy if your epigastric pain suggests upper GI involvement

Advanced Imaging

  • CT enterography or MR enterography for detailed views of small and large intestines
  • Abdominal ultrasound to exclude gallbladder or pancreatic causes of epigastric discomfort

Expert Integration

Dr. Pothuri reviews all findings to differentiate indeterminate colitis from ulcerative colitis or Crohn's disease and tailor your treatment plan.

Bharat Pothuri
Treatment

Our Team offers a full range of care for indeterminate colitis.

1. Diet and Lifestyle Modifications

  • Small, soft meals to ease digestion
  • Avoidance of fatty, dairy, and other trigger foods
  • Frequent hydration to prevent dehydration
  • Stress-reduction techniques such as yoga and deep breathing
  • Support from a dietitian or counselor as needed

2. Medications

  • Anti-inflammatory drugs to calm intestinal swelling
  • Steroids prescribed for short-term flare management
  • Immunosuppressive therapies to modulate an overactive immune response
  • Biologic agents when conventional treatments are insufficient

3. Minimally Invasive or Advanced Procedures

  • Balloon dilation to open narrowed sections of the bowel
  • Laparoscopic surgery to remove severely damaged segments
  • Follow-up imaging and endoscopy for ongoing monitoring and care adjustments
1.5K

Patients Treated

Dr. Pothuri has treated more than 1.5K patients, helping individuals improve their digestive health and overall well-being through expert, personalized care.

20Y

Years of Experience

With over 20 years of experience, GastroDoxs has been a trusted provider of gastroenterology care, focusing on delivering the best outcomes for patients

Bharat Pothuri

About the Author

Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.

Frequently Asked Questions

What is indeterminate colitis?

Indeterminate colitis has features of both ulcerative colitis and Crohn's disease and cannot be definitively classified.

What symptoms occur?

Symptoms include diarrhea, blood in stool, abdominal pain, urgency, and fatigue-similar to other IBD forms.

How is it diagnosed?

Diagnosis requires colonoscopy with biopsies, imaging, and clinical correlation when IBD type remains unclear.

What treatments are used?

Treatment mirrors IBD management aminosalicylates, steroids, immunomodulators, biologics, and surgery if needed.

Does indeterminate colitis change over time?

Yes. Some patients disease behavior evolves, clarifying into Crohn's or ulcerative colitis over months to years.

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