| Brand Name | Akynzeo |
| Generic Name | Netupitant + Palonosetron |
| Drug Class | NK1 Receptor Antagonist |
| Availability | Prescription |
| Manufacturer | Helsinn Therapeutics |
| Indications | Chemotherapy-Induced Nausea and Vomiting (CINV) |
| Type | Capsule |
| Doses | 300 mg netupitant + 0.5 mg palonosetron orally once before chemotherapy |
| Route | Oral |
| Side Effects | Headache, constipation, fatigue, dyspepsia |
| Interactions | May interact with CYP3A4 substrates, serotonin modulators, QT-prolonging drugs |
| Overdose | Overdose symptoms may include severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors. |
| Missed Dose | If you miss a dose, take it as soon as possible. If it's almost time for the next dose, skip the missed dose and resume your regular schedule. Do not double doses. |
| Contraindications | Known hypersensitivity to ingredients; avoid in severe hepatic impairment. |
| Alternatives | Fosaprepitant + Ondansetron, Aprepitant + Granisetron |
| Co-Pay Assistance Program | Available |
| Patient Assistance Program | Available |
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Netupitant + Palonosetron is a combination therapy that acts to prevent chemotherapy-induced Nausea and vomiting by combining an NK1 receptor antagonist (Netupitant) with an isoform called 5-Hydrotryptase (Palonosetron).
The blockers of the neurokinin-1 (NK1) receptor include netupitant, whereas serotonin (5-HT3) receptor blockers include Palonosetron. When used together, they have a wide coverage to avoid acute and delayed nausea and vomiting caused by chemotherapy.
The common side effects are constipation, fatigue, and headache. The side effects are potentially severe such as liver problems or allergy.
Netupitant + Palonosetron is administered orally mostly, normally one hour prior to chemotherapy as a single dose. Your medical professional will tell how much the medicine you should be prescribed.
Netupitant + Palonosetron ought to be administered only when the advantage is more than the harm during pregnancy. A person should not take this drug during pregnancy without consulting a healthcare professional.
In case you are late in taking medication, take it immediately you remember but do not take it close to the next medication. Do not take two doses at once.
Netupitant + Palonosetron is not to kill motion sickness rather to avoid stomach sickness and nausea related with chemotherapy. Ask your doctor about other forms of treatment.
Netupitant + palonosetron normally begins to work in the course of an hour of its administration and can last approximately 5 days following the chemotherapy.
Yes, Netupitant + Palonosetron can have interactions with other drugs especially the liver enzyme one. It is important to mention to your medical caregiver every drug you are prescribed.
Yes, Netupitant + Palonosetron may be combined with other anti-nausea drugs to offer complete protection against nausea and vomiting after the chemo sessions.
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