| Brand Name | Trulance |
| Generic Name | Plecanatide |
| Drug Class | Osmotic Laxative |
| Availability | Prescription |
| Manufacturer | Salix Pharmaceuticals |
| Indications | Constipation |
| Type | Tablet |
| Doses | 3 mg once daily |
| Route | Oral |
| Side Effects | Diarrhea, bloating, abdominal tenderness, flatulence |
| Interactions | No known significant interactions; localized GI effect |
| Overdose | Overdose may cause severe digestive symptoms and electrolyte imbalances. |
| Missed Dose | If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. |
| Contraindications | Pediatric patients under 6 years (risk of dehydration), known or suspected GI obstruction |
| Alternatives | Linaclotide, Lubiprostone, Prucalopride |
| Co-Pay Assistance Program | Available |
| Patient Assistance Program | Not available |
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Plecanatide is applied in managing chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C).
Plecanatide acts by secretion of increasing fluid in the intestines and increasing motility, which overcomes stool softening and promotion of bowel motions.
The typical side effects are nausea, diarrhea, stomach cramps, and bloating. These are the side effects that, with time, the body can get used to and they pass.
Plecanatide is normally administered orally in tablet form one time a day. The proper dosage will depend on your health condition that your healthcare provider will decide.
Plecanatide is not to be administered in case of pregnancy unless this has more benefits over the risks. It should be used only when pregnant and with the help of your health practitioner.
In case you miss one dose, take it immediately when you remember to take it unless its nearly time to take the next dose. Do not take two doses at once.
Most medicines are usually safe to take together with plecanatide although always tell your medical practitioner about all the medications that you are taking.
The onset of plecanatide effect takes around 24-48 hours though it might take even longer in certain cases such as those of IBS-C.
Plecanatide is not normally utilized in diarrhea. When used, it affects the intestines and produces more fluid secretion that may aggravate the symptoms in patients with diarrhea.
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