| Brand Name | Anzemet |
| Generic Name | Dolasetron |
| Drug Class | Antiemetic |
| Availability | Prescription |
| Manufacturer | Sanofi-Aventis |
| Indications | Prevention of nausea and vomiting due to chemotherapy or surgery |
| Type | Tablet, Injection |
| Doses | 100 mg orally, 1.8 mg/kg IV |
| Route | Oral, Intravenous |
| Side Effects | Headache, fatigue, dizziness |
| Interactions | Antiarrhythmic drugs, SSRIs |
| Overdose | Seek emergency help for severe arrhythmia |
| Missed Dose | Take as soon as possible unless close to next dose |
| Contraindications | Hypersensitivity, prolonged QT interval |
| Alternatives | Ondansetron, Granisetron |
| Co-Pay Assistance Program | Available |
| Patient Assistance Program | Available |
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Dolasetron treatments are employed to prevent chemotherapy induced nausea and vomiting and post-surgical nausea and vomiting.
The mechanism of action of dolasetron is that it occupies most of the serotonin receptor within the gastrointestinal tract and the brain and this inhibits the signals that cause nausea and vomiting.
The major side effects are constipation, dizziness, and headache. Arrhythmias (disorders of the heart rhythm) are some of the possible serious side effects.
Dolasetron is mainly used intravenously (IV) in the clinical setting or orally in the prevention of nausea and vomiting in the aftermath of the chemotherapy or surgery.
The administration of Dolasetron in pregnancy should be performed only when the benefits of this drug exceed the harm. One should talk to their healthcare provider about how to use it.
In case you miss a dose, use it immediately after you remember except in case it is nearly the time of your next dose. Do not take two doses at once.
Dolasetron is not normally administered to motion sickness. It is mostly applied in the prevention of chemotherapy-induced nausea and vomiting. Other remedies of motion sickness should be checked with your physician.
Dolasetron usually works within a few hours of administration to prevent nausea and vomiting associated with chemotherapy or surgery.
Yes, dolasetron is capable of interfering with the rhythm of the heart of certain individuals resulting to arrhythmias. This is the reason why cardiac functioning should be monitored during this drug.
Dolasetron may interact with other drugs especially those used in heart rhythm or serotonin. All of the medications that you take should be informed to your doctor.
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