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Zydelig - Idelalisib

Bharat Pothuri Medically Reviewed by Dr. Bharat Pothuri, MD, FACG
Brand Name
Zydelig
Generic Name
Idelalisib
Drug Class
PI3K Inhibitor
Availability
Prescription
Manufacturer
Gilead Sciences
Indications
Ulcerative Colitis, Crohn's Disease
Type
Tablet
Doses
Oral: 150 mg twice daily (induction), 150 mg daily (maintenance)
Route
Oral
Side Effects
Diarrhea, nausea, fatigue, liver enzyme elevation, infections
Interactions
PI3K inhibitor; avoid CYP3A inhibitors and monitor for infections
Overdose
Liver toxicity, diarrhea, infection risk.
Missed Dose
Take ASAP; skip if near next.
Contraindications
Severe hepatic impairment, active TB or serious infections.
Alternatives
Upadacitinib, Filgotinib
Co-Pay Assistance Program
Available Rx
Patient Assistance Program
Available

Frequently Asked Questions

What is Tofacitinib used for?

Tofacitinib is applied in managing mild to moderate to severe rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis with the inhibition of Janus kinase (JAK) enzymes in the inflammatory process.

How does Tofacitinib work?

Tofacitinib is obtained by blocking JAK-enzymes which becomes highly important in the immune system signaling pathways, thereby decreasing inflammation and tissue damages.

What are the side effects of Tofacitinib?

The side effects are upper respiratory infections, headache, and high blood pressure, which are common. Severe side effects are also possible such as blood clots and infections.

How is Tofacitinib taken?

Tofacitinib is administered as pills and is normally taken once or twice in a day, depending on the type of ailment one is afflicted with and the dosage prescribed.

Is Tofacitinib associated with the rise in infections?

Yes, Tofacitinib can cause intense infection. Infection signs and symptoms should be checked, and the doctor should be contacted in case of any symptoms.

Is Tofacitinib safe on pregnancy?

The use of tofacitinib during pregnancy needs to have an advantage over the disadvantage. Talk with your medical practitioner about whether you are pregnant or about having pregnancy.

What in case of a missed dose of Tofacitinib?

In case you miss a dose take the overdue dose immediately you remember until the time of the immediate dose is soon approaching. Do not take two doses at once.

Is it possible to use Tofacitinib in combination with other megations?

Tofacitinib can be used alongside other immunosuppressive drugs hence it is crucial to notify your doctor on all the medications that you take.

What is the time of action of Tofacitinib?

Tofacitinib can require weeks or even months before its effects can be noticed especially in cases such as rheumatoid arthritis and ulcerative colitis.

What is the effectiveness of Tofacitinib in the treatment of ulcerative colitis?

Tofacitinib has demonstrated its efficacy in the treatment of moderate to severe ulcerative colitis to induce and maintain remission in a good number of the individuals.