| Brand Name | Lotronex |
| Generic Name | Alosetron hydrochloride |
| Drug Class | 5-HT3 Receptor Antagonist |
| Availability | Prescription |
| Manufacturer | Prometheus Laboratories |
| Indications | Severe IBS in women |
| Type | Tablet |
| Doses | 0.5-1 mg twice daily |
| Route | Oral |
| Side Effects | Constipation, abdominal pain |
| Interactions | SSRIs, antipsychotics |
| Overdose | Seek immediate medical help |
| Missed Dose | Skip missed dose; do not double up |
| Contraindications | Severe liver disease, ischemic colitis |
| Alternatives | Linzess, Amitiza |
| Co-Pay Assistance Program | Available |
| Patient Assistance Program | Available |
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Alosetron Hydrochloride is used to treat severe irritable bowel syndrome (IBS) in women, particularly those with diarrhea-predominant IBS.
Alosetron works by blocking serotonin receptors in the gastrointestinal tract, which helps to slow down bowel movements and reduce abdominal pain.
Common side effects include constipation, abdominal pain, and nausea. Serious side effects may include ischemic colitis, a condition that can lead to reduced blood flow to the intestines.
Alosetron Hydrochloride is typically taken orally, once daily. The dosage will depend on your doctor�s instructions based on the severity of your symptoms.
Alosetron Hydrochloride should not be used during pregnancy. Consult your healthcare provider for alternative treatments if you are pregnant or planning to become pregnant.
Yes, one of the most common side effects of Alosetron is constipation, which can become severe. If constipation becomes problematic, you should contact your doctor.
It may take up to 4 weeks to notice improvements in IBS symptoms. If there is no improvement, consult your doctor to evaluate your treatment plan.
If you miss a dose, take it as soon as you remember unless it�s almost time for your next dose. Do not take two doses at once.
Alosetron Hydrochloride is approved for use in women with IBS and is not typically prescribed for men due to limited effectiveness in this population.
Alosetron may interact with other medications, especially those that affect bowel function. Always inform your doctor about all medications you are taking.
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