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Akynzeo

Netupitant + Palonosetron

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Akynzeo - Netupitant + Palonosetron

Bharat Pothuri Medically Reviewed by Dr. Bharat Pothuri, MD, FACG
Brand Name
Akynzeo
Generic Name
Netupitant + Palonosetron
Drug Class
NK1 Receptor Antagonist
Availability
Prescription
Manufacturer
Helsinn Therapeutics
Indications
Chemotherapy-Induced Nausea and Vomiting (CINV)
Type
Capsule
Doses
300 mg netupitant + 0.5 mg palonosetron orally once before chemotherapy
Route
Oral
Side Effects
Headache, constipation, fatigue, dyspepsia
Interactions
May interact with CYP3A4 substrates, serotonin modulators, QT-prolonging drugs
Overdose
Overdose symptoms may include severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.
Missed Dose
If you miss a dose, take it as soon as possible. If it's almost time for the next dose, skip the missed dose and resume your regular schedule. Do not double doses.
Contraindications
Known hypersensitivity to ingredients; avoid in severe hepatic impairment.
Alternatives
Fosaprepitant + Ondansetron, Aprepitant + Granisetron
Co-Pay Assistance Program
Available
Patient Assistance Program
Available

Frequently Asked Questions

What is the purpose of Netupitant + Palonosetron?

Netupitant + Palonosetron is a combination therapy that acts to prevent chemotherapy-induced Nausea and vomiting by combining an NK1 receptor antagonist (Netupitant) with an isoform called 5-Hydrotryptase (Palonosetron).

Mechanism of action Netupitant + Palonosetron?

The blockers of the neurokinin-1 (NK1) receptor include netupitant, whereas serotonin (5-HT3) receptor blockers include Palonosetron. When used together, they have a wide coverage to avoid acute and delayed nausea and vomiting caused by chemotherapy.

Which are the most frequently occurring side effects of Netupitant + Palonosetron?

The common side effects are constipation, fatigue, and headache. The side effects are potentially severe such as liver problems or allergy.

What is the recommended route of administration of Netupitant + Palonosetron?

Netupitant + Palonosetron is administered orally mostly, normally one hour prior to chemotherapy as a single dose. Your medical professional will tell how much the medicine you should be prescribed.

Should Netupitant + Palonosetron be used in pregnancy or not?

Netupitant + Palonosetron ought to be administered only when the advantage is more than the harm during pregnancy. A person should not take this drug during pregnancy without consulting a healthcare professional.

How would I take substitution in case of missing dose of Netupitant + Palonosetron?

In case you are late in taking medication, take it immediately you remember but do not take it close to the next medication. Do not take two doses at once.

Is Netupitant + Palonosetron applicable in motion sickness?

Netupitant + Palonosetron is not to kill motion sickness rather to avoid stomach sickness and nausea related with chemotherapy. Ask your doctor about other forms of treatment.

What is the time of action of Netupitant + Palonosetron?

Netupitant + palonosetron normally begins to work in the course of an hour of its administration and can last approximately 5 days following the chemotherapy.

Is Netupitant + Palonosetron likely to interact with any other drugs?

Yes, Netupitant + Palonosetron can have interactions with other drugs especially the liver enzyme one. It is important to mention to your medical caregiver every drug you are prescribed.

Is Netupitant + Palonosetron suitable to be used with other anti-nausea drugs?

Yes, Netupitant + Palonosetron may be combined with other anti-nausea drugs to offer complete protection against nausea and vomiting after the chemo sessions.