| Brand Name | Akynzeo |
| Generic Name | Netupitant + Palonosetron |
| Drug Class | NK1 Receptor Antagonist |
| Availability | Prescription |
| Manufacturer | Helsinn Therapeutics |
| Indications | Chemotherapy-Induced Nausea and Vomiting (CINV) |
| Type | Capsule |
| Doses | 300 mg netupitant + 0.5 mg palonosetron orally once before chemotherapy |
| Route | Oral |
| Side Effects | Headache, constipation, fatigue, dyspepsia |
| Interactions | May interact with CYP3A4 substrates, serotonin modulators, QT-prolonging drugs |
| Overdose | Overdose symptoms may include severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors. |
| Missed Dose | If you miss a dose, take it as soon as possible. If it's almost time for the next dose, skip the missed dose and resume your regular schedule. Do not double doses. |
| Contraindications | Known hypersensitivity to ingredients; avoid in severe hepatic impairment. |
| Alternatives | Fosaprepitant + Ondansetron, Aprepitant + Granisetron |
| Co-Pay Assistance Program | Available |
| Patient Assistance Program | Available |
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Netupitant + Palonosetron is a combination medication used to prevent nausea and vomiting caused by chemotherapy, combining an NK1 receptor antagonist (Netupitant) and a 5-HT3 receptor antagonist (Palonosetron).
Netupitant blocks the neurokinin-1 (NK1) receptor, while Palonosetron blocks the serotonin (5-HT3) receptor. Together, they provide broad coverage to prevent both acute and delayed nausea and vomiting from chemotherapy.
Common side effects include headache, constipation, and fatigue. Serious side effects may include allergic reactions or liver problems.
Netupitant + Palonosetron is typically taken orally as a single dose, usually one hour before chemotherapy. Your healthcare provider will determine the appropriate dosage for your treatment.
Netupitant + Palonosetron should be used during pregnancy only if the benefits outweigh the risks. Consult your healthcare provider before starting this medication during pregnancy.
If you miss a dose, take it as soon as you remember, unless it's almost time for the next dose. Do not take two doses at once.
Netupitant + Palonosetron is specifically designed to prevent nausea and vomiting associated with chemotherapy and not for motion sickness. Discuss alternative treatments with your doctor if needed.
Netupitant + Palonosetron typically starts working within an hour of administration and can provide relief for up to 5 days after chemotherapy.
Yes, Netupitant + Palonosetron may interact with other medications, particularly those that affect liver enzymes. Always inform your healthcare provider about all medications you're taking.
Yes, Netupitant + Palonosetron is often used in combination with other anti-nausea medications to provide comprehensive protection against nausea and vomiting after chemotherapy.
Related Conditions |
Related Blogs |
|---|---|
