| Brand Name | Trulance |
| Generic Name | Plecanatide |
| Drug Class | Osmotic Laxative |
| Availability | Prescription |
| Manufacturer | Salix Pharmaceuticals |
| Indications | Constipation |
| Type | Tablet |
| Doses | 3 mg once daily |
| Route | Oral |
| Side Effects | Diarrhea, bloating, abdominal tenderness, flatulence |
| Interactions | No known significant interactions; localized GI effect |
| Overdose | Overdose may cause severe digestive symptoms and electrolyte imbalances. |
| Missed Dose | If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. |
| Contraindications | Pediatric patients under 6 years (risk of dehydration), known or suspected GI obstruction |
| Alternatives | Linaclotide, Lubiprostone, Prucalopride |
| Co-Pay Assistance Program | Available |
| Patient Assistance Program | Not available |
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Plecanatide is used to treat chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C).
Plecanatide works by increasing fluid secretion in the intestines and enhancing motility, helping to soften stools and promote bowel movements.
Common side effects include diarrhea, stomach cramps, and bloating. These side effects typically resolve as the body adjusts to the medication.
Plecanatide is typically taken orally in tablet form once daily. Your healthcare provider will determine the appropriate dosage based on your condition.
Plecanatide should be used during pregnancy only if the benefits outweigh the risks. Consult your healthcare provider before using it during pregnancy.
If you miss a dose, take it as soon as you remember unless it�s almost time for your next dose. Do not take two doses at once.
Plecanatide is generally safe to use with most other medications, but always inform your healthcare provider about all medications you are taking.
Plecanatide typically starts working within 24 to 48 hours, but it may take longer for full effects, especially for conditions like IBS-C.
Plecanatide is not typically used for diarrhea. It works by increasing fluid secretion in the intestines and may worsen symptoms in individuals with diarrhea.
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