| Brand Name | Rinvoq |
| Generic Name | Upadacitinib |
| Drug Class | Janus Kinase 1 (JAK1) Inhibitor |
| Availability | Prescription |
| Manufacturer | AbbVie |
| Indications | Ulcerative Colitis |
| Type | Tablet |
| Doses | 45 mg once daily |
| Route | Oral |
| Side Effects | Upper respiratory infections, acne, nausea, increased cholesterol levels |
| Interactions | JAK inhibitor; monitor for serious infections, liver enzymes |
| Overdose | Overdose may lead to increased immunosuppression, risk of serious infections, or cardiovascular effects; immediate medical attention recommended. |
| Missed Dose | Take ASAP; must monitor first dose. |
| Contraindications | Severe hepatic impairment, active infection |
| Alternatives | Tofacitinib, Filgotinib |
| Co-Pay Assistance Program | Available Rx |
| Patient Assistance Program | Available |
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Upadacitinib is used to treat moderate to severe rheumatoid arthritis and other inflammatory conditions by targeting specific immune system pathways.
Upadacitinib works by inhibiting Janus kinases (JAKs), enzymes that play a role in the inflammatory process, thus reducing inflammation and tissue damage.
Common side effects include upper respiratory infections, headache, and nausea. Serious side effects may include infections, blood clots, or changes in blood counts.
Upadacitinib is usually taken as an oral tablet once daily. Your healthcare provider will determine the appropriate dose based on your condition.
Yes, Upadacitinib is also used to treat other inflammatory conditions such as psoriatic arthritis, ulcerative colitis, and atopic dermatitis.
Upadacitinib is not recommended during pregnancy unless absolutely necessary. Consult your healthcare provider if you are pregnant or planning to become pregnant.
Upadacitinib may interact with other medications, including vaccines, blood thinners, and certain antibiotics. Always inform your doctor about any medications you're taking.
If you miss a dose, take it as soon as you remember, unless it�s almost time for the next dose. Do not take two doses at once.
Weight gain is not a common side effect of Upadacitinib, but any unusual weight changes should be discussed with your healthcare provider.
Upadacitinib reduces inflammation by targeting specific enzymes in the immune system that contribute to inflammatory responses in conditions like rheumatoid arthritis.
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