| Brand Name | Jyseleca |
| Generic Name | Filgotinib |
| Drug Class | Anti-TL1A Monoclonal Antibody |
| Availability | Prescription |
| Manufacturer | Gilead Sciences |
| Indications | Ulcerative Colitis |
| Type | Tablet |
| Doses | 200 mg daily |
| Route | Oral |
| Side Effects | Nausea, headache, diarrhea, increased infection risk |
| Interactions | JAK1 inhibitor; increased infection risk; monitor CBC |
| Overdose | Increased infection risk, GI symptoms. |
| Missed Dose | Take ASAP. Skip if close to next dose. |
| Contraindications | Severe hepatic impairment, active infection |
| Alternatives | Tofacitinib, Upadacitinib |
| Co-Pay Assistance Program | Available Rx |
| Patient Assistance Program | Available |
Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.
Filgotinib is used to treat moderate to severe rheumatoid arthritis and is being studied for its effectiveness in other inflammatory conditions.
Filgotinib works by selectively inhibiting Janus kinase 1 (JAK1), which plays a key role in the immune response and inflammatory processes in rheumatoid arthritis.
Common side effects include upper respiratory infections, headache, and nausea. Serious side effects may include infections, liver issues, or blood clots.
Filgotinib is taken as an oral tablet once daily. The dosage and length of treatment will be determined by your healthcare provider based on your condition.
Yes, Filgotinib is also being studied for conditions such as ulcerative colitis and Crohn's disease, where inflammation plays a role.
Filgotinib is not recommended during pregnancy. If you are pregnant or planning to become pregnant, consult your doctor before using this medication.
Weight gain is not a typical side effect of Filgotinib. However, any significant changes in weight should be monitored by your healthcare provider.
If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. Do not take two doses at once.
Filgotinib helps reduce inflammation and damage caused by rheumatoid arthritis by targeting JAK1 enzymes that are involved in the immune response.
Filgotinib may interact with other medications, especially those that affect the immune system or liver function. Always inform your doctor of all medications you're taking.
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