Primary Biliary Cirrhosis (also known as Primary Biliary Cholangitis) is a type of chronical liver disease where the minuscule bile ducts within a liver get inflamed and eventually destroyed. These ducts are destroyed and bile accumulates and damages the liver tissue in the long run.
The symptoms of PBC tend to be non-existent initially. As it advances, you may notice:
It is not clear what exactly causes PBC, however, the following factors play an important role:
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PBC is detected by performing a combination of blood tests (anti-mitochondrial antibodies [AMA], alkaline phosphatase [ALP]) and imaging procedures such as MRI or ultrasound and may or may not do a liver biopsy to determine the severity of liver damage.
The first-line PBC medication is Ursodeoxycholic acid (UDCA). It aids in the better passage of bile, lowering the level of liver enzymes, and the pace at which liver damage happens.
No current cure exists to PBC. Nonetheless, symptoms can be managed, the development of the disease may be prolonged, and long-term outcomes will be much better with the help of timely diagnosis and treatment.
Yes. The diet based on fruits, vegetables and whole grains with low fats and with high fibres may help in maintaining the liver. It is also important to be hydrated and reduce alcohol intake.
The inflammation of the bile ducts is called cholangitis. With PBC, inflammation that is chronic ruins over time the small bile ducts of the liver.
Considered regular follow-up after every 3-6 months to administer blood tests, review of the symptoms, and liver function monitoring to redefine the treatment.
PBC can Be managable, and when promptly diagnosed, most patients will have several decades to live. The quality of life is maintained and complications are delayed with the help of regular monitoring and treatment.
Yes. It is superpractical in PBC with chronic itching (pruritus) and dry skin as a result of bile salt build up. These treatments are the antihistamines, topical creams, and bile-acid-modifying drugs.
PBC mostly occurs in women above 40 years of age and such individuals with other autoimmune diseases. Autoimmune liver disease is also risky when the family history reveals it.
PBC stage 4 shows sign of cirrhosis (severe scarring of liver). The management is aimed at the treatment of complications (ascites, encephalopathy), and liver transplant evaluation when possible.
