Michael’s Story: Painless obstructive jaundice from a pancreatic head adenocarcinoma
A 64-year-old retired software architect looking for an explanation for progressive clay-colored stool, dark urine, painless jaundice, poor appetite, and unintended weight loss
Michael was a retired software architect whose first explanation was a minor liver-test fluctuation.
The decision changed when stool stayed gray while appetite and weight declined. The combination of progressive clay-colored stool, dark urine, painless jaundice, poor appetite, and unintended weight loss required a more specific evaluation.
A cholestatic laboratory pattern and duct dilation on ultrasound led to pancreas-protocol imaging and EUS, which identified a pancreatic head mass; tissue sampling established adenocarcinoma and staging guided care.
The final plan used multidisciplinary biliary drainage when indicated, surgical resectability review, oncology treatment, nutrition support, and pruritus management. Follow-up measured safety, symptom resolution, objective recovery, and the risk of recurrence.
Painless jaundice with weight loss required a pancreatic and bile-duct pathway, not watchful waiting.